ArticlePloS one2016
Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Metabolic syndrome, hypertension, and hyperglycemia were positively associated with knee osteoarthritis, while dyslipidemia showed no association with knee osteoarthritis.Clinical rheumatology · 2021Pooled it
- Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study.The Korean journal of internal medicine · 2026Article
- Mapping the intersection of social status and comorbidity in knee osteoarthritis: A WOMAC-based study.PloS one · 2026Article
- Hypertension is associated with knee osteoarthritis pain in an age-dependent manner.Experimental gerontology · 2025Article
- Shared Mechanisms Between Osteoarthritis and Cardiovascular Disease: A Clinical and Pathophysiological Review.Cureus · 2025Review
- An evaluation of knee osteoarthritis pain in the general community-Asir region, Saudi Arabia.PloS one · 2024Article
- The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis.Cureus · 2023Article
- Joint Injury, Osteoarthritis, and Cardiovascular Disease Risk Factors in Former National Football League Athletes: An NFL-LONG Study.Journal of athletic training · 2023Article
- Osteoarthritis and Diabetes: Where Are We and Where Should We Go?Diagnostics (Basel, Switzerland) · 2023Review
- Chair stand test as a proxy for physical performance and muscle strength in sarcopenia diagnosis: the Korean frailty and aging cohort study.Aging clinical and experimental research · 2022Article
- Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies.Journal of orthopaedic translation · 2022Review
- High Estimated 24-Hour Urinary Sodium Excretion Is Related to Symptomatic Knee Osteoarthritis: A Nationwide Cross-Sectional Population-Based Study.The journal of nutrition, health & aging · 2022Article
- High-Intensity Interval Training for Knee Osteoarthritis: A Pilot Study.ACR open rheumatology · 2021Article
- Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis.Nature reviews. Rheumatology · 2021Review
- The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China's rural population.Scientific reports · 2021Article
- Associations of Comorbid Conditions and Transitions Across States of Knee Osteoarthritis in a Community-Based Cohort.ACR open rheumatology · 2021Article
- Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis.F1000Research · 2021Article
- The prevalence of type 2 diabetes and associated risk factors with generalized osteoarthritis: a retrospective study using ICD codes for clinical data repository system.Clinical rheumatology · 2019Article
- Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Exploring Cerebrovascular Function in Osteoarthritis: "Heads-up".Physiological reports · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors.
methodsA total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis. Knee osteoarthritis patients were defined as participants with K-L grade ≥2 on knee X-ray regardless of knee pain. The association between major cardiovascular risk factors (blood pressure, diabetes, cholesterol, and smoking habits), FRS, and knee osteoarthritis was analyzed, adjusting for various covariates.
resultsPrevalence of knee osteoarthritis in Koreans aged ≥50 years was 36.6%, and higher in women (men: 24.9%, women: 45.4%). Prevalence of knee osteoarthritis in participants with hypertension was significantly higher than those without hypertension (fully adjusted odds ratio (OR) 1.26; 95% confidence interval (CI) 1.08-1.48). Knee osteoarthritis prevalence was also higher in participants with impaired fasting glucose or diabetes than those without (age, sex adjusted OR 1.19; 95% CI 1.00-1.41). Also, OR values increased statistically significantly with FRS as a continuous variable (fully adjusted OR 1.007; 95% CI 1.00-1.01).
conclusionsPrevalence of knee osteoarthritis was associated with hypertension and diabetes, which are major cardiovascular risk factors, and the FRS. Further studies on FRS pertaining to its relationship with osteoarthritis are warranted.
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