ArticlePloS one2016
Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Epigenetic signatures of local adaptation: differential expression of long non-coding RNAs in reciprocally transplantedFrontiers in immunology · 2026Article
- Decoding Local Adaptation in the Exploited Native Marine MusselInternational journal of molecular sciences · 2025Article
- Hypoxia in the Blue MusselGenes · 2024Article
- Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel (Mytilus chilensis).Biological research · 2024Article
- Contamination Status and Risk Assessment of Paralytic Shellfish Toxins in Shellfish along the Coastal Areas of China.Marine drugs · 2024Article
- Epigenetic variation mediated by lncRNAs accounts for adaptive genomic differentiation of the endemic blue musselHeliyon · 2024Article
- Article
- The Caspase Homologues in ScallopToxins · 2022Article
- Marine Neurotoxins' Effects on Environmental and Human Health: An OMICS Overview.Marine drugs · 2021Review
- In Vitro Effects of Paralytic Shellfish Toxins and Lytic Extracellular Compounds Produced byToxins · 2021Article
- Growth Performance and Transcriptomic Response of Warm-Acclimated Hybrid Abalone Haliotis rufescens (♀) × H. corrugata (♂).Marine biotechnology (New York, N.Y.) · 2021Article
- Adaptive Differences in Gene Expression in Farm-Impacted Seedbeds of the Native Blue MusselFrontiers in genetics · 2021Article
- Article
- Experimental exposure of the mussel Mytilus platensis (d'Orbigny, 1842) to the dinoflagellate Alexandrium catenella from Argentine Patagonia.Ecotoxicology (London, England) · 2020Article
- Article
- Article
- The evolution of ependymin-related proteins.BMC evolutionary biology · 2018Article
- Article
- Integrative Biomarker Assessment of the Influence of Saxitoxin on Marine Bivalves: A Comparative Study of the Two Bivalve Species Oysters,Frontiers in physiology · 2018Article
- Comparative immunogenomics of molluscs.Developmental and comparative immunology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saxitoxin (STX), a principal phycotoxin contributing to paralytic shellfish poisoning, is largely produced by marine microalgae of the genus Alexandrium. This toxin affects a wide range of species, inducing massive deaths in fish and other marine species. However, marine bivalves can resist and accumulate paralytic shellfish poisons. Despite numerous studies on the impact of STX in marine bivalves, knowledge regarding STX recognition at molecular level by benthic species remains scarce. Therefore, the aim of this study was to identify novel genes that interact with STX in the Chilean mussel Mytilus chilensis. For this, RNA-seq and RT-qPCR approaches were used to evaluate the transcriptomic response of M. chilensis to a purified STX as well as in vivo Alexandrium catenella exposure. Approximately 800 million reads were assembled, generating 138,883 contigs that were blasted against the UniProt Mollusca database. Pattern Recognition Receptors (PRRs) involved in mussel immunity, such as Toll-like receptors, tumor necrosis factor receptors, and scavenger-like receptors were found to be strongly upregulated at 8 and 16 h post-STX injection. These results suggest an involvement of PRRs in the response to STX, as well as identifying potential, novel STX-interacting receptors in this Chilean mussel. This study is the first transcriptomic overview of the STX-response in the edible species M. chilensis. However, the most significant contribution of this work is the identification of immune receptors and pathways potentially involved in the recognition and defense against STX's toxicity and its impact of harmful algae blooms on wild and cultivated mussel populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.