ArticlePloS one2016
Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- The Capacities of the Probiotic StrainsBiomolecules · 2025Article
- Fexofenadine HCl enhances growth, biofilm, and lactic acid production of Limosilactobacillus reuteri and Bifidobacterium longum: implications for allergy treatment.BMC microbiology · 2025Article
- Profiling of the gut, skin and nasal microbiotas revealed clinically relevant microbial taxa from children with allergies: a pilot study.Frontiers in allergy · 2025Article
- Antibacterial and antibiofilm activity of human gut lactic acid bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Targeting Food Allergy with Probiotics.Advances in experimental medicine and biology · 2024Review
- Mechanisms of interleukin-10 induction in murine spleen and RAW264 cells byBioscience of microbiota, food and health · 2024Article
- Review
- Lactic Acid Bacteria Isolated from Fresh Vegetable Products: Potential Probiotic and Postbiotic Characteristics Including Immunomodulatory Effects.Microorganisms · 2022Article
- Metaproteomics insights into fermented fish and vegetable products and associated microbes.Food chemistry. Molecular sciences · 2021Review
- Association of Intestinal Microbial Dysbiosis With Chronic Obstructive Pulmonary Disease.Cureus · 2021Review
- The beneficial effects of ultraviolet light supplementation on bone density are associated with the intestinal flora in rats.Applied microbiology and biotechnology · 2021Article
- Review
- Article
- Isolation and characterization of high exopolysaccharide-producing Weissella confusa VP30 from young children's feces.Microbial cell factories · 2019Article
- Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice.World journal of microbiology & biotechnology · 2019Article
- Altered Gut Microbiota Diversity and Composition in Chronic Urticaria.Disease markers · 2019Article
- Oral Intake ofIndian journal of microbiology · 2018Article
- Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion.Journal of radiation research · 2018Article
- Dual Effects of Alpha-Hydroxy Acids on the Skin.Molecules (Basel, Switzerland) · 2018Review
- Double-Stranded RNA Derived from Lactic Acid Bacteria Augments Th1 ImmunityFrontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some studies reported that probiotic could relieve allergy-induced damage to the host, but how to get a useful probiotic is still a challenge. In this study, the protective effects of three lactic acid bacteria (La, Lp and Lc) were evaluated in a mouse model, and its relationship with the in vitro properties was analyzed. The in vitro results indicated that La with the capacity to inhibit IL-4 production could have a better anti-allergy effect in vivo than two others. However, the animal trials showed that all LAB strains could alleviate allergen-induced airway inflammation. Among them, LAB strain Lp had a better effect in inhibiting allergic response through a modulation of Th1/Th2 balance and an increase of regulatory T cells. This difference could be explained by that different LAB strains have a strain-specific effect on gut microbiota closely associated with host immune responses. Finally, this study did not only obtain an effective anti-allergy probiotic strain via animal study, but also indicate that probiotic-induced effect on intestinal microbiota should be considered as an important screening index, apart from its inherent characteristics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.