ArticlePloS one2016
Outcomes in Critically Ill Patients with Cancer-Related Complications.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Understanding Outcomes in Onco-critical Care: The Role of Frailty and Organ Failure.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Brazilian Research in Intensive Care Network (BRICNet): shaping the landscape of critical care research in Brazil and beyond.Critical care science · 2025Review
- ICU-acquired infections in immunocompromised patients.Intensive care medicine · 2024Review
- Critically ill metastatic cancer patients returning home after unplanned ICU stay: an observational, multicentre retrospective study.Annals of intensive care · 2023Article
- Etiologies and Outcome of Patients with Solid Tumors Admitted to ICU with Acute Respiratory Failure: A Secondary Analysis of the EFRAIM Study.Respiratory care · 2023Article
- Sarcoma Patients Admitted to the Intensive Care Unit (ICU): Predictive Relevance of Common Sepsis and Performance Parameters.Cancer management and research · 2023Article
- Association and risk factors of healthcare-associated infection and burden of illness among chemotherapy-induced ulcerative mucositis patients.Clinical oral investigations · 2022Article
- Case Report: Case report: Non-invasive mechanical ventilation in combination with bronchoscopy in the treatment of respiratory failure of lung cancer patient.F1000Research · 2022Article
- Patterns of ICU admissions and outcomes in patients with solid malignancies over the revolution of cancer treatment.Annals of intensive care · 2021Article
- Fluoroquinolone treatment as a protective factor for 10-day mortality in Streptococcus pneumoniae bacteremia in cancer patients.Scientific reports · 2021Article
- Critically ill patients with cancer: A clinical perspective.World journal of clinical oncology · 2020Review
- Management of cancer patients during COVID-19 pandemic at developing countries.World journal of clinical cases · 2020Review
- Characteristics and outcomes of patients with solid tumors receiving chemotherapy in the intensive care unit.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- The impact of the duration of the palliative care period on cancer patients with regard to the use of hospital services and the place of death: a retrospective cohort study.BMC palliative care · 2020Article
- Comparative Effectiveness of Proton vs Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer.JAMA oncology · 2020Article
- Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study.Journal of cancer research and clinical oncology · 2018Article
- In-hospital and day-120 survival of critically ill solid cancer patients after discharge of the intensive care units: results of a retrospective multicenter study-A Groupe de recherche respiratoire en réanimation en Onco-Hématologie (Grrr-OH) study.Annals of intensive care · 2018Article
- Pre-existing malignancy results in increased prevalence of distinct populations of CD4+ T cells during sepsis.PloS one · 2018Article
- Prognostic factors of noninvasive mechanical ventilation in lung cancer patients with acute respiratory failure.PloS one · 2018Observational
Corrections and comments
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Authors and funding
16 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCancer patients are at risk for severe complications related to the underlying malignancy or its treatment and, therefore, usually require admission to intensive care units (ICU). Here, we evaluated the clinical characteristics and outcomes in this subgroup of patients. MATERIALS AND
methodsSecondary analysis of two prospective cohorts of cancer patients admitted to ICUs. We used multivariable logistic regression to identify variables associated with hospital mortality.
resultsOut of 2,028 patients, 456 (23%) had cancer-related complications. Compared to those without cancer-related complications, they more frequently had worse performance status (PS) (57% vs 36% with PS≥2), active malignancy (95% vs 58%), need for vasopressors (45% vs 34%), mechanical ventilation (70% vs 51%) and dialysis (12% vs 8%) (P<0.001 for all analyses). ICU (47% vs. 27%) and hospital (63% vs. 38%) mortality rates were also higher in patients with cancer-related complications (P<0.001). Chemo/radiation therapy-induced toxicity (6%), venous thromboembolism (5%), respiratory failure (4%), gastrointestinal involvement (3%) and vena cava syndrome (VCS) (2%) were the most frequent cancer-related complications. In multivariable analysis, the presence of cancer-related complications per se was not associated with mortality [odds ratio (OR) = 1.25 (95% confidence interval, 0.94-1.66), P = 0.131]. However, among the individual cancer-related complications, VCS [OR = 3.79 (1.11-12.92), P = 0.033], gastrointestinal involvement [OR = 3.05 (1.57-5.91), P = <0.001] and respiratory failure [OR = 1.96(1.04-3.71), P = 0.038] were independently associated with in-hospital mortality.
conclusionsThe prognostic impact of cancer-related complications was variable. Although some complications were associated with worse outcomes, the presence of an acute cancer-related complication per se should not guide decisions to admit a patient to ICU.
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