ArticlePLoS genetics2016
The QTL GNP1 Encodes GA20ox1, Which Increases Grain Number and Yield by Increasing Cytokinin Activity in Rice Panicle Meristems.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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109 citing papers in PubMed, 265 citations in OpenAlex.
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- The current state of the use of DNA markers for improving the efficiency of rice breeding in Japan.Breeding science · 2026Article
- The DTH8-SD1 pair regulates panicle architecture in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Systematic mutagenesis reveals dominant-minor paralog configurations in the riceFrontiers in plant science · 2026Article
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- The RING-domain E3 ubiquitin ligase OsRGLG6 regulates rice grain number and yield via ubiquitination-mediated degradation of OsOTUB1.aBIOTECH · 2025Article
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- Feeding the future: Genetic gatekeepers provide more rice grains per plant.Plant physiology · 2025Article
- OsBIR3 maintains the homeostasis of OsBRI1, OsREM4.1, and Brd2 protein levels in brassinosteroid pathways in rice.Plant biotechnology journal · 2025Article
- Transcriptome analysis of two photo-thermo-sensitive genic male-sterile lines reveal GA-mediated regulatory mechanism for rice panicle exsertion.BMC genomics · 2025Article
- Correlation of rice yield based on RILs population QTL analysis.BMC genomic data · 2025Article
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- MaGA20ox2f, an OsSD1 homolog, regulates flowering time and fruit yield in banana.Molecular breeding : new strategies in plant improvement · 2025Article
- Differential ABA sensitivity of superior and inferior rice grains is linked to cell cycle entry into endoreduplication.Frontiers in plant science · 2025Article
- Identification of quantitative trait loci for yield traits and fine-mapping ofFrontiers in plant science · 2025Article
- CRISPR/Cas9- and Cas3-mediated modification of copy number variation in rice.Frontiers in genome editing · 2025Article
- GIBBERELLIN PERCEPTION SENSOR 2 reveals genesis and role of cellular GA dynamics in light-regulated hypocotyl growth.The Plant cell · 2024Article
- A point mutation in VIG1 boosts development and chilling tolerance in rice.Nature communications · 2024Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinins and gibberellins (GAs) play antagonistic roles in regulating reproductive meristem activity. Cytokinins have positive effects on meristem activity and maintenance. During inflorescence meristem development, cytokinin biosynthesis is activated via a KNOX-mediated pathway. Increased cytokinin activity leads to higher grain number, whereas GAs negatively affect meristem activity. The GA biosynthesis genes GA20oxs are negatively regulated by KNOX proteins. KNOX proteins function as modulators, balancing cytokinin and GA activity in the meristem. However, little is known about the crosstalk among cytokinin and GA regulators together with KNOX proteins and how KNOX-mediated dynamic balancing of hormonal activity functions. Through map-based cloning of QTLs, we cloned a GA biosynthesis gene, Grain Number per Panicle1 (GNP1), which encodes rice GA20ox1. The grain number and yield of NIL-GNP1TQ were significantly higher than those of isogenic control (Lemont). Sequence variations in its promoter region increased the levels of GNP1 transcripts, which were enriched in the apical regions of inflorescence meristems in NIL-GNP1TQ. We propose that cytokinin activity increased due to a KNOX-mediated transcriptional feedback loop resulting from the higher GNP1 transcript levels, in turn leading to increased expression of the GA catabolism genes GA2oxs and reduced GA1 and GA3 accumulation. This rebalancing process increased cytokinin activity, thereby increasing grain number and grain yield in rice. These findings uncover important, novel roles of GAs in rice florescence meristem development and provide new insights into the crosstalk between cytokinin and GA underlying development process.
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