Evidence map›Paper›PMID 27763997›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2016

Closing the Gap in Antiretroviral Initiation and Viral Suppression: Time Trends and Racial Disparities.

Charles F Haines, John A Fleishman, Baligh R Yehia, Bryan Lau, Stephen A Berry, Allison L Agwu, Richard D Moore, Kelly A Gebo

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Charles F Haines*Department of Medicine, Division of Infectious Disease, The John Hopkins School of Medicine, Baltimore, MD;†Agency for Healthcare Research and Quality (AHRQ);‡University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA;§Department of Epidemiology, The Johns Hopkins University School of Public Health, Baltimore, MD; and‖The Johns Hopkins Department of Pediatrics, Division of Infectious Diseases, Baltimore, MD.
John A Fleishman
Baligh R Yehia
Bryan Lau
Stephen A Berry
Allison L Agwu
Richard D Moore
Kelly A Gebo
Johns Hopkins Medicine · USJohns Hopkins University · USAgency for Healthcare Research and Quality · USUniversity of Pennsylvania · US

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel · 1994 to 2026
$78.4M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
Institute for Clinical and Translational Research (KL2)KL2RR025006 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$12.9M
HIV DISEASE OUTCOMES IN DRUG USERS IN CLINICAL PRACTICER01DA011602 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 1998 to 2013
$10.8M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
Alcohol and HIV Treatment and Clinical ProgressionR01AA016893 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2008 to 2011
$1.3M
Universal Screening of HIV-Infected Persons for Gonorrhea and ChlamydiaK23AI084854 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BERRY, STEPHEN ARTHUR · 2010 to 2014
$671k
HAART Initiation in Behaviorally HIV-Infected YouthK23AI084549 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AGWU, ALLISON L · 2010 to 2013
$537k
Evaluating Patient Retention in HIV CareK23MH097647 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI YEHIA, BALIGH RAMZI · 2012 to 2013
$361k
CLINICAL OUTCOMES IN ELDERLY HIV PATIENTSR01AG026250 · NIA · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2006 to 2007
$197k
NCRR NIH HHS KL2 RR025006NIAAA NIH HHS R01 AA016893NIAID NIH HHS K23 AI084549NIAID NIH HHS K23 AI084854NIAID NIH HHS P30 AI036214NIAID NIH HHS P30 AI094189NIA NIH HHS R01 AG026250NIDA NIH HHS K24 DA000432NIDA NIH HHS R01 DA011602NIDA NIH HHS U01 DA036935NIMH NIH HHS K23 MH097647
6 · The paper itself

Abstract

backgroundIn the current antiretroviral (ART) era, the evolution of HIV guidelines and emergence of new ART agents might be expected to impact the times to ART initiation and HIV virologic suppression. We sought to determine if times to AI and virologic suppression decreased and if disparities exist by age, race/ethnicity, and HIV risk.

methodsWe performed a retrospective cohort study of data from 12 sites of the HIV Research Network, a consortium of US clinics caring for HIV-infected patients. HIV-infected adults (≥18 year old) newly presenting for care between 2003 and 2013 were included in this study. Times to AI and virologic suppression were defined as time from enrollment to AI and HIV RNA <400 copies per milliliter, respectively. We conducted time-to-event analyses using competing risk regression in the HIV Research Network cohort from 2003 to 2012 in 2-year intervals, with follow-up through 2013.

resultsAmong 15,272 participants, 76.9% were male, 48.4% black, and 10.9% were injection drug use with median age of 38 years (interquartile range: 29-46 years). The adjusted subdistribution hazards ratios (SHRs) for AI and virologic suppression each increased for years 2007-2008 [SHR 1.23 (1.16-1.30), and SHR 1.25 (1.17-1.34), respectively], 2009-2010 [1.55 (1.46-1.64), and 1.54 (1.43-1.65), respectively], and 2011-2012 [1.94 (1.83-2.07), and 1.73 (1.61-1.86), respectively] compared with 2003-2004. Blacks had a lower probability of AI than whites and Hispanics.

conclusionsSince 2007, times from enrollment to AI and virologic suppression have decreased significantly compared with 2003-2004, but persisting disparities should be addressed.

Indexed as

Antiretroviral Therapy, Highly ActiveHealth Status DisparitiesAdultAmbulatory CareBlack or African AmericanBlack PeopleCD4 Lymphocyte CountFemaleFollow-Up StudiesHispanic or LatinoHIV InfectionsHumansMaleMiddle AgedRetrospective StudiesTime Factors

Identifiers

PMID27763997
PMCPMC5119893
OpenAlexW2472179517

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.