ArticlePsychosomatic medicine
Mechanisms Underlying the Association Between Early-Life Adversity and Physical Health: Charting a Course for the Future.
Article in Psychosomatic medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions to Support Children's Recovery From Neglect-A Systematic Review.Child maltreatment · 2024Pooled it
- Socioeconomic Status and Cardiovascular Responses to Standardized Stressors: A Systematic Review and Meta-Analysis.Psychosomatic medicine · 2018Pooled it
- Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women With Early Life Abuse: A Randomized Controlled Trial.Psychosomatic medicineTrial
- Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries.BMC medicine · 2026Article
- The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Impact of family childhood adversity on risk of violence and involvement with police in adolescence: findings from the UK Millennium Cohort Study.Journal of epidemiology and community health · 2025Article
- Intergenerational educational mobility and mental health: Evidence from a Filipino birth cohort.PLOS global public health · 2025Article
- Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study.Wellcome open research · 2024Article
- The relationship between lifecourse traumatic events and pain in an older rural South African population: A cross-sectional study.PloS one · 2024Article
- Sex differences in the association of adverse childhood experiences on past 30-day opioid misuse among Florida justice-involved children.Journal of substance abuse treatment · 2022Article
- Early life adversity has long-term effects on sociality and interaction style in female baboons.Proceedings. Biological sciences · 2022Article
- Developmental Consequences of Early Life Stress on Risk for Psychopathology: Longitudinal Associations with Children's Multisystem Physiological Regulation and Executive Functioning.Development and psychopathology · 2021Article
- Levels of Emotional Awareness: Theory and Measurement of a Socio-Emotional Skill.Journal of Intelligence · 2021Review
- Statistical methods for mediation analysis in the era of high-throughput genomics: Current successes and future challenges.Computational and structural biotechnology journal · 2021Review
- Adverse childhood experiences: Mechanisms of risk and resilience in a longitudinal urban cohort.Development and psychopathology · 2020Article
- The long arm of childhood experiences on longevity: Testing midlife vulnerability and resilience pathways.Psychology and aging · 2019Article
- Childhood adversity and women's cardiometabolic health in adulthood: associations with health behaviors, psychological distress, mood symptoms, and personality.BMC women's health · 2019Article
- Interleukin-6 and Depressive Mood Symptoms: Mediators of the Association Between Childhood Abuse and Cognitive Performance in Middle-Aged Adults.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- Exposure to traumatic events in childhood predicts cortisol production among high risk pregnant women.Biological psychology · 2018Article
- The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.Epigenomics · 2018Article
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3 authors.
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Abstract
Early-life adversities (ELA) are associated with subsequent pervasive alterations across a wide range of neurobiological systems and psychosocial factors that contribute to accelerated onset of health problems and diseases. In this article, we provide an integrated perspective on recent developments in research on ELA, based on the articles published in this Special Issue of Psychosomatic Medicine. We focus on the following: 1) the distinction between specific versus general aspects of ELA with regard to the nature of exposure (e.g., physical and sexual abuse, emotional abuse or neglect, relative socioeconomic deprivation), biological and behavioral correlates of ELA, and differences across diseases; 2) the importance of timing in the critical phases of exposure to ELA; and 3) adaptive versus dysfunctional responses to ELA and their consequences for biological and behavioral risk factors for adverse health outcomes. This article concludes with outlining important new targets for research in this area, including the neurobiology of affect as a mechanism linking ELA to adverse health outcomes, and the need for large-scale longitudinal investigations of multisystem processes relevant to ELA in diverse samples, starting prenatally, continuing to late adolescence, and with long-term follow-up assessments that enable evaluation of incident disease outcomes.
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