ReviewRNA biology2017
Uptake and impact of natural diet-derived small RNA in invertebrates: Implications for ecology and agriculture.
Review in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Oral Delivery of miR146a Conjugated to Cerium Oxide Nanoparticles Improves an Established T Cell-Mediated Experimental Colitis in Mice.Pharmaceutics · 2024Article
- Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts.International journal of molecular sciences · 2022Review
- RNAs on the Go: Extracellular Transfer in Insects with Promising Prospects for Pest Management.Plants (Basel, Switzerland) · 2021Review
- Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA's Activities and Perspective.Frontiers in plant science · 2020Review
- Plant miRNA Cross-Kingdom Transfer Targeting Parasitic and Mutualistic Organisms as a Tool to Advance Modern Agriculture.Frontiers in plant science · 2020Review
- The Catenulida flatworm can express genes from its microbiome or from the DNA it ingests.Scientific reports · 2019Article
- Host Plant-Derived miRNAs Potentially Modulate the Development of a Cosmopolitan Insect Pest,Biomolecules · 2019Article
- Using problem formulation for fit-for-purpose pre-market environmental risk assessments of regulated stressors.EFSA journal. European Food Safety Authority · 2019Article
- MicroRNAs from plants to animals, do they define a new messenger for communication?Nutrition & metabolism · 2018Review
- Evidence for plant-derived xenomiRs based on a large-scale analysis of public small RNA sequencing data from human samples.PloS one · 2018Article
- RNA as a means of inter-species communication and manipulation: Progresses and shortfalls.RNA biology · 2017Article
- Bioavailability of transgenic microRNAs in genetically modified plants.Genes & nutrition · 2017Article
- Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals.Genes & nutrition · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The putative transfer and gene regulatory activities of diet-derived small RNAs (sRNAs) in ingesting animals are still debated. The existence of natural uptake of diet-derived sRNA by invertebrate species could have significant implication for our understanding of ecological relationships and could synergize with efforts to use RNA interference (RNAi) technology in agriculture. Here, we synthesize information gathered from studies in invertebrates using natural or artificial dietary delivery of sRNA and from studies of sRNA in vertebrate animals and plants to review our current understanding of uptake and impact of natural diet-derived sRNA on invertebrates. Our understanding has been influenced and sometimes confounded by the diversity of invertebrates and ingested plants studied, our limited insights into how gene expression may be modulated by dietary sRNAs at the mechanistic level, and the paucity of studies focusing directly on natural uptake of sRNA. As such, we suggest 2 strategies to investigate this phenomenon more comprehensively and thus facilitate the realization of its potentially broad impact on ecology and agriculture in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.