Evidence map›Paper›PMID 27763630›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2017

Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants.

M Stavel, J Wong, Z Cieslak, R Sherlock, M Claveau, P S Shah

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  4. Indomethacin for symptomatic patent ductus arteriosus in preterm infants.The Cochrane database of systematic reviews · 2021
    Pooled it
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  8. Review
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  11. Review
  12. Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Observational
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

M StavelNeonatal Intensive Care Unit, Royal Columbian Hospital, New Westminster, BC, Canada.
J WongDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Z CieslakNeonatal Intensive Care Unit, Royal Columbian Hospital, New Westminster, BC, Canada.
R SherlockNeonatal Intensive Care Unit, Surrey Memorial Hospital, Surrey, BC, Canada.
M ClaveauDepartment of Pediatrics, McGill University Health Centre, Montreal, QC, Canada.
P S ShahDepartment of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
University of Toronto · CAMcGill University Health Centre · CAMount Sinai Hospital · CARoyal Columbian Hospital · CASurrey Memorial Hospital · CA

Funding

CIHR APR-126340CIHR FRN87518
6 · The paper itself

Abstract

objectiveTo determine the effect of concomitant administration of prophylactic indomethacin and early enteral feeds on the risk of spontaneous intestinal perforation (SIP) in extremely low-birth-weight (ELBW) infants, and to describe the variation in prophylactic indomethacin use in Canada. STUDY

designA retrospective cohort study of 4268 ELBW infants born at <30 weeks' gestation admitted to Canadian neonatal units between 2010 and 2014 was conducted. Prophylactic indomethacin (I+ or I-, administered within 24 h) and early feeding (E+ or E-, initiated in the first 2 days) exposures were studied concurrently and independently. The primary outcomes were SIP and death before discharge. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated.

resultsCompared with the I-/E+ reference group (n=1829), infants in I+/E+ (n=285; aOR 2.92, 95% CI 1.41 to 6.08) and I+/E- (n=213; aOR 2.84, 95% CI 1.35 to 5.98) groups had higher odds of SIP, whereas those in the I-/E- group had similar odds (n=1941; aOR 1.37, 95% CI 0.88 to 2.14). Odds of SIP were higher in the indomethacin exposed group (I+) compared with the unexposed (I-) group when controlled for early feeding (aOR 2.43, 95% CI 1.41 to 4.19), but not in the early feeding group when controlled for indomethacin. The use of prophylactic indomethacin ranged from 0% usage in 13 sites to 78% use in one site.

conclusionProphylactic indomethacin was associated with increased odds of SIP independently from early feeding in this cohort; however, early enteral feeding was not associated with SIP. Marked variation in the use of prophylactic indomethacin was identified.

Indexed as

Enteral NutritionInfant, Extremely Low Birth WeightCanadaCerebral Intraventricular HemorrhageDatabases, FactualFemaleGestational AgeHumansIndomethacinInfant, Extremely PrematureInfant, NewbornIntestinal PerforationMalePatient DischargeRetrospective StudiesTreatment OutcomeIndomethacin

Identifiers

PMID27763630
OpenAlexW2537483211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.