Evidence map›Paper›PMID 27763551›Full record

ArticleToxins2016

The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus).

Daryl C Yang, Jennifer R Deuis, Daniel Dashevsky, James Dobson, Timothy N W Jackson, Andreas Brust, Bing Xie, Ivan Koludarov, Jordan Debono, Iwan Hendrikx and 10 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Tiny but Mighty:Toxins · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Pharmacological Screening of Venoms from Five BrazilianInternational journal of molecular sciences · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. The journal of venomous animals and toxins including tropical diseases · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Daryl C YangDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton 3168, Australia. daryl.yang@monash.edu.
Jennifer R DeuisInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. j.deuis@uq.edu.au.
Daniel DashevskyVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. danieldashevsky@gmail.com.
James DobsonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. james.dobson@uqconnect.edu.au.
Timothy N W JacksonVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. tnwjackson@gmail.com.
Andreas BrustInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. a.brust@imb.uq.edu.au.
Bing XieBejing Genomics Institute-Shenzhen, Shenzhen 518083, China. xiebing@genomics.cn.
Ivan KoludarovVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. jcoludar@gmail.com.
Jordan DebonoVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. jordan_debono@hotmail.com.
Iwan HendrikxVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. iwanhx@yahoo.com.
Wayne C HodgsonDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton 3168, Australia. wayne.hodgson@monash.edu.
Peter JoshSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia 4072, Australia. p.josh@uq.edu.au.
Amanda NouwensSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia 4072, Australia. a.nouwens@uq.edu.au.
Gregory J BaillieInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. g.baillie@imb.uq.edu.au.
Timothy J C BruxnerInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. t.bruxner@imb.uq.edu.au.
Paul F AlewoodInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. p.alewood@imb.uq.edu.au.
Kelvin Kok Peng LimLee Kong Chian Natural History Museum, National University of Singapore, 2 Conservatory Drive, Singapore 117377, Singapore. kelvinlim@nus.edu.sg.
Nathaniel FrankMtoxins, 1111 Washington ave, Oshkosh, WI 54901, USA. nate@mtoxins.com.
Irina VetterInstitute for Molecular Bioscience, University of Queensland, St. Lucia 4072, Australia. i.vetter@imb.uq.edu.au.
Bryan G FryVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. bgfry@uq.edu.au.
The University of Queensland · AUAustralian Regenerative Medicine Institute · AUBGI Group (China) · CNNational University of Singapore · SGOshkosh (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Millions of years of evolution have fine-tuned the ability of venom peptides to rapidly incapacitate both prey and potential predators. Toxicofera reptiles are characterized by serous-secreting mandibular or maxillary glands with heightened levels of protein expression. These glands are the core anatomical components of the toxicoferan venom system, which exists in myriad points along an evolutionary continuum. Neofunctionalisation of toxins is facilitated by positive selection at functional hotspots on the ancestral protein and venom proteins have undergone dynamic diversification in helodermatid and varanid lizards as well as advanced snakes. A spectacular point on the venom system continuum is the long-glanded blue coral snake (

Indexed as

ElapidaeAnimalsCell Line, TumorChickensElapid VenomsHEK293 CellsHumansMaleMuscle, SkeletalNAV1.4 Voltage-Gated Sodium ChannelNeurotoxinsVoltage-Gated Sodium Channel AgonistsElapid VenomsNAV1.4 Voltage-Gated Sodium ChannelNeurotoxinsVoltage-Gated Sodium Channel Agonistsevolutionneurotoxinpharmacologysodium channeltoxicoferavenom

Identifiers

PMID27763551
PMCPMC5086663
OpenAlexW2536507227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.