ReviewJournal of neurotrauma2017
Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.
Review in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04807764 (Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury), which is not on this map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury
Who cites it
62 citing papers in PubMed, 107 citations in OpenAlex.
- Cervical and thoracolumbar transspinal stimulation at 0.3 Hz and 30 Hz facilitates neuronal excitability in healthy humans: a randomized cross-over study.Experimental brain research · 2025Trial
- Restoration of gamma-aminobutyric acid homeostasis: A novel approach to alleviating central nervous system injury-associated immunodepression syndrome.Neural regeneration research · 2026Article
- Human-machine Interface using functional electrostimulation and inertial sensors for lower limb rehabilitation in spinal cord injury individuals: a proof of concept.Medical & biological engineering & computing · 2026Article
- Evaluation of blood flow restriction combined with routine rehabilitation in incomplete thoracic and lumbar spinal cord injury after decompression: a retrospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Research progress on the effects of epidural electrical stimulation on lower extremity function in patients with spinal cord injury.Frontiers in medicine · 2026Review
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
- Hyperreflexia after corticospinal tract lesion reflects 1 A afferent circuit changes not increased KCC2 hyperexcitability.Experimental neurology · 2025Article
- Detailed Kinematic Analysis Reveals Subtleties of Recovery from Contusion Injury in the Rat Model with DREADDs Afferent Neuromodulation.Bioengineering (Basel, Switzerland) · 2025Article
- Recruitment Challenges in Spinal Cord Stimulation Trial for Motor Recovery in Patients with Chronic Complete Spinal Cord Injury.Journal of clinical medicine · 2025Article
- Mechanism-Based Neuromodulation in Augmenting Respiratory Motor Function in Individuals with Spinal Cord Injury.Journal of clinical medicine · 2025Review
- The conformal, high-density SpineWrap microelectrode array for focal stimulation and selective muscle recruitment.Advanced functional materials · 2025Article
- Rehabilitation Perspectives in Spinal Cord Ischemia After Major Vascular Surgery: A Case Series.Journal of musculoskeletal & neuronal interactions · 2025Observational
- Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section.Journal of materials science. Materials in medicine · 2025Article
- Multiparametric MRI Assessment of Morpho-Functional Muscle Changes Following a 6-Month FES-Cycling Training Program: Pilot Study in People With a Complete Spinal Cord Injury.JMIR rehabilitation and assistive technologies · 2025Article
- Clinical features and rehabilitation outcome after surgical treatment of spinal meningioma.Spinal cord series and cases · 2024Article
- Exercise Volume Can Modulate the Regenerative Response to Spinal Cord Injury in Mice.Neurotrauma reports · 2024Article
- Effects of exoskeleton-assisted walking on bowel function in motor-complete spinal cord injury patients: involvement of the brain-gut axis, a pilot study.Frontiers in neuroscience · 2024Article
- Article
- Sensory Information Modulates Voluntary Movement in an Individual with a Clinically Motor- and Sensory-Complete Spinal Cord Injury: A Case Report.Journal of clinical medicine · 2023Article
- Transcranial magnetic stimulation-based closed-loop modality for activity of daily living gain in spinal cord injury: a retrospective study using propensity score matching analysis.European journal of physical and rehabilitation medicine · 2023Observational
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Body-weight supported locomotor training (BWST) promotes recovery of load-bearing stepping in lower mammals, but its efficacy in individuals with a spinal cord injury (SCI) is limited and highly dependent on injury severity. While animal models with complete spinal transections recover stepping with step-training, motor complete SCI individuals do not, despite similarly intensive training. In this review, we examine the significant differences between humans and animal models that may explain this discrepancy in the results obtained with BWST. We also summarize the known effects of SCI and locomotor training on the muscular, motoneuronal, interneuronal, and supraspinal systems in human and non-human models of SCI and address the potential causes for failure to translate to the clinic. The evidence points to a deficiency in neuronal activation as the mechanism of failure, rather than muscular insufficiency. While motoneuronal and interneuronal systems cannot be directly probed in humans, the changes brought upon by step-training in SCI animal models suggest a beneficial re-organization of the systems' responsiveness to descending and afferent feedback that support locomotor recovery. The literature on partial lesions in humans and animal models clearly demonstrate a greater dependency on supraspinal input to the lumbar cord in humans than in non-human mammals for locomotion. Recent results with epidural stimulation that activates the lumbar interneuronal networks and/or increases the overall excitability of the locomotor centers suggest that these centers are much more dependent on the supraspinal tonic drive in humans. Sensory feedback shapes the locomotor output in animal models but does not appear to be sufficient to drive it in humans.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.