ArticleScientific reports2016
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase.
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Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
52 citing papers in PubMed, 97 citations in OpenAlex.
- Compensatory pathways in tryptophan metabolism and immune regulation following IDO inhibition.Molecular biology reports · 2026Review
- Evidence for the Formation of an Iron(III)-Indolenylperoxo Intermediate During Indole Dioxygenation: Similarities with Heme Dioxygenases.Inorganic chemistry · 2026Article
- Human IDO2 exhibits unique binding affinities distinct to those of human IDO1.The FEBS journal · 2026Article
- Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE.Angewandte Chemie (International ed. in English) · 2025Article
- Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.Molecular metabolism · 2025Article
- MicrobeRX: a tool for enzymatic-reaction-based metabolite prediction in the gut microbiome.Microbiome · 2025Article
- Review
- IDO and TDO inhibitors in cancer immunotherapy: mechanisms, clinical development, and future directions.Frontiers in pharmacology · 2025Review
- Molecular Insights Into the Interaction of Tryptophan Metabolites With Tryptophan and Indoleamine 2,3-Dioxygenases: Nitric Oxide a New Effector of Tryptophan 2,3-Dioxygenase and Their Roles in Infection.International journal of tryptophan research : IJTR · 2025Article
- Secondary Sphere Lewis Acid Activated Heme Superoxo Adducts Mimic Crucial Non-Covalent Interactions in IDO/TDO Heme Dioxygenases.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Heme-based dioxygenases: Structure, function and dynamics.Journal of inorganic biochemistry · 2024Review
- Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2.Scientific reports · 2024Article
- The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects.International journal of molecular sciences · 2024Review
- The high-affinity tryptophan uptake transport system in human cells.Biochemical Society transactions · 2024Review
- Exploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation.Scientific reports · 2024Article
- Enzymatic reactions towards aldehydes: An overview.Flavour and fragrance journal · 2023Review
- The Role of Heme Peroxo Oxidants in the Rational Mechanistic Modeling of Nitric Oxide Synthase: Characterization of Key Intermediates and Elucidation of the Mechanism.Angewandte Chemie (International ed. in English) · 2022Article
- The Epigenetics of Psychosis: A Structured Review with Representative Loci.Biomedicines · 2022Review
- Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport.The Journal of nutrition · 2022Article
- Systemic tryptophan homeostasis.Frontiers in molecular biosciences · 2022Review
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Authors and funding
13 authors at 4 institutions in 1 country.
Ariel Lewis-BallesterDepartment of Physiology and Biophysics Albert Einstein College of Medicine Bronx, NY 10461, USA.
Farhad ForouharDepartment of Biological Sciences Northeast Structural Genomics Consortium Columbia University New York, NY 10027, USA.
Sung-Mi KimDepartments of Cellular and Molecular Pharmacology, Pharmaceutical Chemistry, and Bioengineering and Therapeutic Sciences, The Liver Center, University of California at San Francisco San Francisco, CA 94158, USA.
Scott LewDepartment of Biological Sciences Northeast Structural Genomics Consortium Columbia University New York, NY 10027, USA.
YongQiang WangDepartments of Cellular and Molecular Pharmacology, Pharmaceutical Chemistry, and Bioengineering and Therapeutic Sciences, The Liver Center, University of California at San Francisco San Francisco, CA 94158, USA.
Shay KarkashonDepartment of Physiology and Biophysics Albert Einstein College of Medicine Bronx, NY 10461, USA.
Jayaraman SeetharamanDepartment of Biological Sciences Northeast Structural Genomics Consortium Columbia University New York, NY 10027, USA.
Dipanwita BatabyalDepartment of Physiology and Biophysics Albert Einstein College of Medicine Bronx, NY 10461, USA.
Bing-Yu ChiangDepartment of Physiology and Biophysics Albert Einstein College of Medicine Bronx, NY 10461, USA.
Munif HussainDepartment of Biological Sciences Northeast Structural Genomics Consortium Columbia University New York, NY 10027, USA.
Maria Almira CorreiaDepartments of Cellular and Molecular Pharmacology, Pharmaceutical Chemistry, and Bioengineering and Therapeutic Sciences, The Liver Center, University of California at San Francisco San Francisco, CA 94158, USA.
Syun-Ru YehDepartment of Physiology and Biophysics Albert Einstein College of Medicine Bronx, NY 10461, USA.
Liang TongDepartment of Biological Sciences Northeast Structural Genomics Consortium Columbia University New York, NY 10027, USA.
Albert Einstein College of Medicine · USNew York Structural Biology Center · USUniversity of California, San Francisco · USColumbia University · US
Funding
Sub-project 9U54GM074958 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI MONTELIONE, GAETANO T · 2005 to 2009
$56.6MSTRUCTURAL GENOMICS OF EUKARYOTIC MODEL ORGANISMSP50GM062413 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI MONTELIONE, GAETANO T · 2000 to 2004
$33.5MUCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7MHEPATIC DEGRADATION OF P450P ISOZYMESR01GM044037 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 1990 to 2023
$8.0MREGULATION OF HEME METABOLISM IN THE LIVERR01DK026506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 1986 to 2016
$7.1MBio-Organic Biomedical Mass Spectromy ResourceP41GM103481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURLINGAME, ALMA L · 2012 to 2015
$6.4MStructure and Function of Heme-based DioxygenasesR01GM115773 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI YEH, SYUN-RU · 2016 to 2023
$3.3MCatalytic and Inhibitory Mechanisms in Indoleamine 2,3-dioxygenaseR01GM086482 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI YEH, SYUN-RU · 2010 to 2013
$1.3MInfluence of Heme on Hepatic Cytochrome P450 Synthesis and DegradationR56DK026506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 2007 to 2007
$500kNIDDK NIH HHS P30 DK026743NIDDK NIH HHS R01 DK026506NIDDK NIH HHS R56 DK026506NIGMS NIH HHS P41 GM103481NIGMS NIH HHS P50 GM062413NIGMS NIH HHS R01 GM044037NIGMS NIH HHS R01 GM086482NIGMS NIH HHS R01 GM115773NIGMS NIH HHS U54 GM074958
Abstract
Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan metabolism and are involved in many cellular and disease processes. Here we report the crystal structure of human TDO (hTDO) in a ternary complex with the substrates L-Trp and O
Indexed as
Protein Structure, SecondaryCatalysisCrystallography, X-RayHumansIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineOxygenProtein BindingTryptophanTryptophan OxygenaseIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineN'-formylkynurenineOxygenTryptophanTryptophan Oxygenase
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