ArticleScientific reports2016
Aberration-free volumetric high-speed imaging of in vivo retina.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- High-speed full-field swept-source dynamic optical coherence tomography enabled by neural-network-based image generation.Biomedical optics express · 2026Article
- Robust wavefront correction using AdamW-enhanced SPGD for computational adaptive optics in optical coherence tomography.Biomedical optics express · 2026Article
- Coefficient-metric gradient-based digital wavefront correction for full-field swept-source optical coherence tomography.Biomedical optics express · 2026Article
- Dynamic full-field swept-source optical coherence tomography for high-resolution, long-depth, and intratissue-activity imaging.Biomedical optics express · 2026Article
- High-resolution dynamic full-field optical coherence microscopy: illuminating intracellular activity in deep tissue.Npj imaging · 2026Article
- Computational framework for combining multiple swept-sources for high-resolution in-vivo optical coherence tomography.Biomedical optics express · 2026Article
- Computational aberration correction enables full-thickness retinal imaging with adaptive optics optical coherence tomography.Biocybernetics and biomedical engineering · 2026Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Image formation theory of optical coherence tomography with optical aberrations and its application to computational aberration correction.Biomedical optics express · 2025Article
- All-opticalPhotoacoustics · 2025Article
- Digital aberration correction for enhanced thick tissue imaging exploiting aberration matrix and tilt-tilt correlation from the optical memory effect.Nature communications · 2025Article
- Aberration compensation in Doppler holography of the human eye fundus by subaperture signal correlation.Biomedical optics express · 2024Article
- Article
- Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images.Biomedical optics express · 2024Article
- Polarization-resolved analysis of outer retinal bands: investigating ballistic and multiply scattered photons using full-field swept-source optical coherence tomography.Biomedical optics express · 2024Article
- Article
- Line-field dynamic optical coherence tomography platform for volumetric assessment of biological tissues.Biomedical optics express · 2024Article
- K-Space Approach in Optical Coherence Tomography: Rigorous Digital Transformation of Arbitrary-Shape Beams, Aberration Elimination and Super-Refocusing beyond Conventional Phase Correction Procedures.Sensors (Basel, Switzerland) · 2024Article
- Real-time line-field optical coherence tomography for cellular resolution imaging of biological tissue.Biomedical optics express · 2024Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Certain topics in research and advancements in medical diagnostics may benefit from improved temporal and spatial resolution during non-invasive optical imaging of living tissue. However, so far no imaging technique can generate entirely diffraction-limited tomographic volumes with a single data acquisition, if the target moves or changes rapidly, such as the human retina. Additionally, the presence of aberrations may represent further difficulties. We show that a simple interferometric setup-based on parallelized optical coherence tomography-acquires volumetric data with 10 billion voxels per second, exceeding previous imaging speeds by an order of magnitude. This allows us to computationally obtain and correct defocus and aberrations resulting in entirely diffraction-limited volumes. As demonstration, we imaged living human retina with clearly visible nerve fiber layer, small capillary networks, and photoreceptor cells. Furthermore, the technique can also obtain phase-sensitive volumes of other scattering structures at unprecedented acquisition speeds.
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