ArticleScientific reports2016
Dim light at night disturbs the daily sleep-wake cycle in the rat.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 116 citations in OpenAlex.
- Chronic exposure to artificial light at night dampens rhythms in locomotor activity, metabolism, and sleep in female mice.Physiology & behavior · 2026Article
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathy.bioRxiv : the preprint server for biology · 2026Article
- Immunohistochemical expression of pancreatic melatonin receptor (MTNR1B) under experimental sleep disturbance in rats.Journal of molecular histology · 2026Article
- Constant light disrupts biological rhythms and worsens sleep quality but does not elevate blood pressure in female rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Effects of the Probiotics Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 on Anxiety-Related and Emotional Behaviors in Male Wistar Rats Under an Altered Light-Dark Cycle.Brain and behavior · 2025Article
- Sexually dimorphic and clock gene-specific effects of artificial light at night onProceedings. Biological sciences · 2025Article
- Ecology of timekeeping: feeding times effect clock-controlled behavior, metabolism and reproduction in diurnal vertebrates.Npj biological timing and sleep · 2025Review
- Perinatal Photoperiod Has Long-Term Effects on the Rest-Activity Cycle and Sleep in Male and Female Mice.Journal of biological rhythms · 2025Article
- Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rate in stabled riding school horses (Equus caballus).PloS one · 2025Article
- One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike.Journal of biological rhythms · 2024Review
- Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance.Archives of toxicology · 2024Review
- Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat.Frontiers in physiology · 2024Article
- Optimised Stable Lighting Strengthens Circadian Clock Gene Rhythmicity in Equine Hair Follicles.Animals : an open access journal from MDPI · 2023Article
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- Dim light at night affects the locomotor activity of nocturnal African pygmy mice (Proceedings. Biological sciences · 2023Article
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Artificial Dim Light at Night during Pregnancy Can Affect Hormonal and Metabolic Rhythms in Rat Offspring.International journal of molecular sciences · 2022Article
- Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of ~25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.