ArticleScientific reports2016
3D mapping of elastic modulus using shear wave optical micro-elastography.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques.Journal of biomedical science · 2026Review
- A Low-Cost Laser Interferometric Elastography System for Skin Elasticity Measurement.Bioengineering (Basel, Switzerland) · 2026Article
- Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025Review
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography.Biomedical optics express · 2023Article
- Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Ultrafast ultrasound imaging of surface acoustic waves induced by laser excitation compared with acoustic radiation force.Optics letters · 2020Article
- Laser-induced elastic wave classification: thermoelastic versus ablative regimes for all-optical elastography applications.Journal of biomedical optics · 2020Article
- In-vivo 3D corneal elasticity using air-coupled ultrasound optical coherence elastography.Biomedical optics express · 2019Article
- Advances in Doppler optical coherence tomography and angiography.Translational biophotonics · 2019Article
- Characterization of oviduct ciliary beat frequency using real time phase resolved Doppler spectrally encoded interferometric microscopy.Biomedical optics express · 2019Article
- Simultaneously imaging and quantifyingAPL photonics · 2019Article
- Super-shear evanescent waves for non-contact elastography of soft tissues.Applied physics letters · 2019Article
- Computational analysis of six optical coherence tomography systems for vocal fold imaging: A comparison study.Lasers in surgery and medicine · 2019Article
- Does group velocity always reflect elastic modulus in shear wave elastography?Journal of biomedical optics · 2019Article
- Microscale Interrogation of 3D Tissue Mechanics.Frontiers in bioengineering and biotechnology · 2019Review
- Comparisons and Combined Application of Two-Dimensional and Three-Dimensional Real-time Shear Wave Elastography in Diagnosis of Thyroid Nodules.Journal of Cancer · 2019Article
- Acoustic radiation force optical coherence elastography for elasticity assessment of soft tissues.Applied spectroscopy reviews · 2019Article
- Automated 3D segmentation of methyl isocyanate-exposed rat trachea using an ultra-thin, fully fiber optic optical coherence endoscopic probe.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves. In this study, we developed acoustic radiation force (ARF) orthogonal excitation optical coherence elastography (ARFOE-OCE) to visualize shear waves in 3D. This method uses acoustic force perpendicular to the OCT beam to excite shear waves in internal specimens and uses Doppler variance method to visualize shear wave propagation in 3D. The measured propagation of shear waves agrees well with the simulation results obtained from finite element analysis (FEA). Orthogonal acoustic excitation allows this method to measure the shear modulus in a deeper specimen which extends the elasticity measurement range beyond the OCT imaging depth. The results show that the ARFOE-OCE system has the ability to noninvasively determine the 3D elastic map.
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Registered trials
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