Evidence map›Paper›PMID 27761798›Full record

ArticleIrish journal of medical science2017

Colonisation with extended-spectrum beta-lactamase (ESBL) not detected in a prevalence study.

C O'Connor, M G Kiernan, C Finnegan, J Powell, L Power, N H O'Connell, C P Dunne

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Article in Irish journal of medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C O'ConnorDepartment of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland.
M G KiernanCentre for Interventions in Infection, Inflammation and Immunity (4i) and Graduate-Entry Medical School, University of Limerick, Limerick, Ireland.
C FinneganDepartment of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland.
J PowellDepartment of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland.
L PowerDepartment of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland.
N H O'ConnellDepartment of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland.
C P DunneCentre for Interventions in Infection, Inflammation and Immunity (4i) and Graduate-Entry Medical School, University of Limerick, Limerick, Ireland. colum.dunne@ul.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Mid-West of Ireland has higher than average national rates of invasive extended-spectrum beta-lactamase (ESBL) bloodstream infections and carbapenemase-producing Enterobacteriaceae (CPE), with increasing numbers of ESBL isolates detected in community-dwelling patients.

aimsTo conduct a point prevalence study in a convenience sample of the Mid-West population with the aim of determining the extent of ESBL colonisation.

methodsUtilising anonymised community stool samples that had completed routine analysis, we conducted a point prevalence study over a 4-week period on all samples that met defined inclusion and exclusion criteria. Limited epidemiological data was recorded: (1) age of patient, (2) gender, and (3) sender location. From these stool specimens, rectal swabs were inoculated (eSwab™ 480CE, Copan, Italy), which were subsequently cultured on selective chromogenic agar (Colorex™ ESBL). Culture plates were incubated aerobically at 37 °C for 24 h.

resultsOf 195 samples processed, 58 % (n = 112) were from females. The median patient age was 62.4 years (range 20-94 years). 186 samples (95 %) originated from general practitioner clinics. During the study period, only nine eligible stool samples were received from LTCF (6 public). From 195 Colorex™ ESBL chromogenic agar plates cultured, no ESBL-producing organisms were detected.

conclusionsThis community point prevalence study did not identify ESBL colonisation despite high numbers of patients with invasive ESBL bloodstream infections presenting for admission in our institution. We believe this may be because of our small sample size. Data regarding antimicrobial exposure and other risk factors for ESBL colonisation were also not available. We remain vigilant for ESBL-producing organisms.

Indexed as

AdultAgedAged, 80 and overbeta-LactamasesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceYoung Adultbeta-LactamasesExtended-spectrum beta-lactamase (ESBL)-producing EnterobacteriaceaeIrelandPoint prevalence studyRectal carriage

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.