Evidence map›Paper›PMID 27761789›Full record

ReviewReviews in endocrine & metabolic disorders2016

Skin steroidogenesis in health and disease.

Georgios Nikolakis, Constantine A Stratakis, Theodora Kanaki, Andrej Slominski, Christos C Zouboulis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. The exposomal imprint on rosacea: More than skin deep.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  3. Article
  4. Article
  5. Cutaneous Hormone Sampling and Analysis for Dermatologic Research.The Journal of investigative dermatology · 2025
    Review
  6. Review
  7. Evidenced-based approach facilitates choosing between different topical compounds in acne vulgaris.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Insulin and the sebaceous gland function.Frontiers in physiology · 2023
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Seasonal changes in steroid and thyroid hormone content in shed skins of the tegu lizard Salvator merianae.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Georgios NikolakisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany. georgios.nikolakis@klinikum-dessau.de.
Constantine A StratakisSection on Endocrinology and Genetics, NICHD, NIH, Bethesda, MD, USA.
Theodora KanakiDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.
Andrej SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Christos C ZouboulisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
6 · The paper itself

Abstract

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

Indexed as

Nutritional Physiological PhenomenaSkin DiseasesSkin Physiological PhenomenaHumansSteroidsSteroids5a-reductaseAcneAndrogen receptorAndrogensAromataseDermatoendocrinologyDHEAEstrogensGlucocorticoidsRosaceaSteroidogenesisSteroidsTestosterone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.