Evidence map›Paper›PMID 27761730›Full record

Trial reportNeurocritical care2017

Influence of Glycemic Control on Endogenous Circulating Ketone Concentrations in Adults Following Traumatic Brain Injury.

Stephanie M Wolahan, Mayumi L Prins, David L McArthur, Courtney R Real, David A Hovda, Neil A Martin, Paul M Vespa, Thomas C Glenn

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Modulation of cerebral ketone metabolism following traumatic brain injury in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Stephanie M WolahanDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA. swolahan@mednet.ucla.edu.
Mayumi L PrinsDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
David L McArthurDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
Courtney R RealDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
David A HovdaDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
Neil A MartinDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
Paul M VespaDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
Thomas C GlennDepartment of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, University of California - Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

The effects of glycemic control on post-traumatic brain metabolismP01NS058489 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VESPA, PAUL M · 2009 to 2013
$6.2M
Ketone flux and oxidation following human TBI: Implications for cerebral metabolismR21NS093136 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GLENN, THOMAS C. · 2015 to 2016
$424k
NINDS NIH HHS P01 NS058489NINDS NIH HHS R21 NS093136
6 · The paper itself

Abstract

backgroundThe objective was to investigate the impact of targeting tight glycemic control (4.4-6.1 mM) on endogenous ketogenesis in severely head-injured adults.

methodsThe data were prospectively collected during a randomized, within-patient crossover study comparing tight to loose glycemic control, defined as 6.7-8.3 mM. Blood was collected periodically during both tight and loose glycemic control epochs. Post hoc analysis of insulin dose and total nutritional provision was performed.

resultsFifteen patients completed the crossover study. Total ketones were increased 81 μM ([38 135], p < 0.001) when blood glucose was targeted to tight (4.4-6.1 mM) compared with loose glycemic control (6.7-8.3 mM), corresponding to a 60 % increase. There was a significant decrease in total nutritional provisions (p = 0.006) and a significant increase in insulin dose (p = 0.008).

conclusionsPermissive underfeeding was tolerated when targeting tight glycemic control, but total nutritional support is an important factor when treating hyperglycemia.

Indexed as

Outcome Assessment, Health CareAdultBlood GlucoseBrain Injuries, TraumaticCross-Over StudiesFemaleHumansHyperglycemiaKetone BodiesMaleMiddle AgedYoung AdultBlood GlucoseKetone BodiesGlucoseGlycemic controlInsulinKetone bodies

Identifiers

PMID27761730
PMCPMC5336412
OpenAlexW2537632080

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.