Evidence map›Paper›PMID 27761709›Full record

ArticleEuropean radiology2017

Magnetic Resonance Parkinsonism Index: diagnostic accuracy of a fully automated algorithm in comparison with the manual measurement in a large Italian multicentre study in patients with progressive supranuclear palsy.

Salvatore Nigro, Gennarina Arabia, Angelo Antonini, Luca Weis, Andrea Marcante, Alessandro Tessitore, Mario Cirillo, Gioacchino Tedeschi, Stefano Zanigni, Giovanna Calandra-Buonaura and 10 more

Abstract readComparative StudyEvaluation StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. A novelFrontiers in neurology · 2024
    Article
  7. Review
  8. Article
  9. Article
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  13. The Role of Clinical Assessment in the Era of Biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 1 country.

Salvatore NigroInstitute of Bioimaging and Molecular Physiology, National Research Council, 88100, Catanzaro, Italy.
Gennarina ArabiaInstitute of Neurology, Department of Medical and Surgical Sciences, University 'Magna Graecia', 88100, Catanzaro, Italy.
Angelo AntoniniParkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
Luca WeisParkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
Andrea MarcanteParkinson's Disease and Movement Disorders Unit, 'Fondazione Ospedale San Camillo' - I.R.C.C.S, Venice-Lido, Italy.
Alessandro TessitoreDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.
Mario CirilloDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.
Gioacchino TedeschiDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, 80138, Italy.
Stefano ZanigniFunctional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy.
Giovanna Calandra-BuonauraDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Caterina TononFunctional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy.
Gianni PezzoliParkinson Institute, ASST G.Pini - CTO, ex ICP, Milano, Italy.
Roberto CiliaParkinson Institute, ASST G.Pini - CTO, ex ICP, Milano, Italy.
Mario ZappiaDepartment 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
Alessandra NicolettiDepartment 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
Calogero Edoardo CiceroDepartment 'G.F. Ingrassia', Section of Neurosciences, University of Catania, Catania, Italy.
Michele TinazziDepartment of Neurological and Movement Sciences, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
Pierluigi ToccoDepartment of Neurological and Movement Sciences, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
Nicolò CardobiInstitute of Radiology, University Hospital of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.
Aldo QuattroneInstitute of Bioimaging and Molecular Physiology, National Research Council, 88100, Catanzaro, Italy. quattrone@unicz.it.
Ospedale generale di zona San Camillo Treviso · ITUniversity of Catania · ITUniversity of Verona · ITIstituti Clinici di Perfezionamento · ITMagna Graecia University · ITPoliclinico S.Orsola-Malpighi · ITUniversity of Naples Federico II · ITInstitute of Molecular Bioimaging and Physiology · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the reliability of a new in-house automatic algorithm for calculating the Magnetic Resonance Parkinsonism Index (MRPI), in a large multicentre study population of patients affected by progressive supranuclear palsy (PSP) or Parkinson's disease (PD), and healthy controls (HC), and to compare the diagnostic accuracy of the automatic and manual MRPI values.

methodsThe study included 88 PSP patients, 234 PD patients and 117 controls. MRI was performed using both 3T and 1.5T scanners. Automatic and manual MRPI values were evaluated, and accuracy of both methods in distinguishing PSP from PD and controls was calculated.

resultsNo statistical differences were found between automated and manual MRPI values in all groups. The automatic MRPI values differentiated PSP from PD with an accuracy of 95 % (manual MRPI accuracy 96 %) and 97 % (manual MRPI accuracy 100 %) for 1.5T and 3T scanners, respectively.

conclusionOur study showed that the new in-house automated method for MRPI calculation was highly accurate in distinguishing PSP from PD. Our automatic approach allows a widespread use of MRPI in clinical practice and in longitudinal research studies. KEY POINTS: • A new automatic method for calculating the MRPI is presented. • Automatic MRPI values are in good agreement with manual values. • Automatic MRPI can distinguish patients with PSP from patients with PD. • The automatic method overcomes MRPI application limitations in routine practice. • The automatic method may allow a more widespread use of MRPI.

Indexed as

AlgorithmsAgedFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedParkinson DiseaseReproducibility of ResultsSensitivity and SpecificitySupranuclear Palsy, ProgressiveAutomatic segmentationMagnetic Resonance Parkinsonism IndexNeurodegenerative diseaseParkinson’s diseaseProgressive supranuclear palsy

Identifiers

PMID27761709
OpenAlexW2537500048

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.