Evidence map›Paper›PMID 27761693›Full record

Trial reportInflammopharmacology2016

Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial.

Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Inflammopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105840 (Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu), which is not on this map. Cited by 61 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105840 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu

TypeinterventionalSponsorGadjah Mada UniversityRan2023 to 2023Enrolled70ConditionsOsteoarthritis, KneeArmsAcupressure and Standardized Curcuminoid from Turmeric Extract, Sham Acupressure and Placebo
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  9. Efficacy and Safety of Curcumin andFrontiers in immunology · 2022
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shobhit SrivastavaDepartment of Pharmacology and Therapeutics, King George's Medical University, Chowk, Lucknow, 226003, India.
Anil K SaksenaDepartment of Pharmacology and Therapeutics, King George's Medical University, Chowk, Lucknow, 226003, India. saksenaa54@yahoo.co.in.
Sanjay KhattriDepartment of Pharmacology and Therapeutics, King George's Medical University, Chowk, Lucknow, 226003, India.
Santosh KumarDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow, India.
Raghubendra Singh DagurCentre for Advance Research, King George's Medical University, Lucknow, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCurcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects. Therefore, we planned to evaluate the efficacy of CL in KOA.

methodsThe study was designed as a randomized, double-blind, placebo-controlled trial in patients of KOA. After obtaining ethical clearance and written informed consent, a total of 160 patients of KOA were randomly enrolled into two groups to receive either CL extract or placebo along with the standard drug regimen. The patients were assessed on day 0, day 60, and day 120. On the days of their visit, the clinical prognosis was assessed by visual analog scale (VAS) and Western Ontario and McMaster Universities (WOMAC) Osteoarthritis index. On these days, the radiographs were also taken for Kellgren and Lawrence grading and blood samples were collected for assessing the changes in levels of IL-1β and biomarkers of oxidative stress, such as reactive oxygen species and malondialdehyde (MDA).

resultsOver all significant improvement was observed in the patients of CL extract group as compared to placebo group. Clinically, the VAS and WOMAC scores became better, and simultaneously, the levels of biomarkers, viz., IL-1β, ROS, and MDA, were also significantly (p < 0.05) improved.

conclusionIt may be concluded that on chronic administration, CL suppresses inflammation and brings clinical improvement in patients of KOA, which may be observed by decreased level of IL-1β and VAS/WOMAC scores, respectively. At the same time, CL decreases the oxidative stress also.

Indexed as

Anti-Inflammatory AgentsBiomarkersCurcumaDouble-Blind MethodFemaleHumansInterleukin-1betaMaleMalondialdehydeMiddle AgedOsteoarthritis, KneeOxidative StressPain MeasurementPlant ExtractsReactive Oxygen SpeciesRecovery of FunctionAnti-Inflammatory AgentsBiomarkersInterleukin-1betaMalondialdehydePlant ExtractsReactive Oxygen SpeciesCurcuma longa L.Inflammatory biomarkersOsteoarthritis of kneeWOMAC

Identifiers

PMID27761693

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.