Evidence map›Paper›PMID 27761679›Full record

ArticleAIDS and behavior2017

Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.

G Abongomera, A Cook, V Musiime, C Chabala, M Lamorde, J Abach, M Thomason, V Mulenga, A Kekitiinwa, R Colebunders and 3 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

G AbongomeraJoint Clinical Research Centre, Gulu, Uganda. gabongomera@jcrc.org.ug.
A CookMedical Research Council Clinical Trials Unit at University College London, London, UK.
V MusiimeJoint Clinical Research Centre, Kampala, Uganda.
C ChabalaUniversity Teaching Hospital, Lusaka, Zambia.
M LamordeInfectious Diseases Institute, Kampala, Uganda.
J AbachJoint Clinical Research Centre, Gulu, Uganda.
M ThomasonMedical Research Council Clinical Trials Unit at University College London, London, UK.
V MulengaUniversity Teaching Hospital, Lusaka, Zambia.
A KekitiinwaBaylor-Uganda, Kampala, Uganda.
R ColebundersFaculty of Medicine, University of Antwerp, Antwerp, Belgium.
C KityoJoint Clinical Research Centre, Kampala, Uganda.
A S WalkerMedical Research Council Clinical Trials Unit at University College London, London, UK.
D M GibbMedical Research Council Clinical Trials Unit at University College London, London, UK.

Funding

Medical Research Council MC_U122886353Medical Research Council MC_UU_12023/17Medical Research Council MC_UU_12023/26
6 · The paper itself

Abstract

A high level of adherence to antiretroviral treatment is essential for optimal clinical outcomes in HIV infection, but measuring adherence is difficult. We investigated whether responses to a questionnaire eliciting caregiver beliefs in medicines were associated with adherence of their child (median age 2.8 years), and whether this in turn was associated with viral suppression. We used the validated beliefs in medicine questionnaire (BMQ) to measure caregiver beliefs, and medication event monitoring system caps to measure adherence. We found significant associations between BMQ scores and adherence, and between adherence and viral suppression. Among children initiating Antiretroviral therapy (ART), we also found significant associations between BMQ 'necessity' scores, and BMQ 'necessity-concerns' scores, and later viral suppression. This suggests that the BMQ may be a valuable tool when used alongside other adherence measures, and that it remains important to keep caregivers well informed about the long-term necessity of their child's ART.

Indexed as

Attitude to HealthCaregiversMedication AdherenceAbacavirAfrica South of the SaharaAlkynesAnti-HIV AgentsBenzoxazinesChildChild, PreschoolCyclopropanesDideoxynucleosidesFemaleHIV InfectionsHumansInfantAbacavirAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesDideoxynucleosidesefavirenzLamivudineNevirapineStavudineZidovudineAdherenceAntiretroviral therapyBeliefs in medicineChildrenSub-Saharan Africa

Identifiers

PMID27761679
PMCPMC5288435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.