SynthesisRheumatology international2016
Does the initiation of urate-lowering treatment during an acute gout attack prolong the current episode and precipitate recurrent attacks: a systematic literature review.
Synthesis in Rheumatology international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Efficacy of initiating urate-lowering therapy during an acute gout episode: a meta-analysis.Zeitschrift fur Rheumatologie · 2023Pooled it
- Korean guidelines for the management of gout.The Korean journal of internal medicine · 2023Guideline
- The clinical efficacy of urate-lowering therapy in acute gout: a meta-analysis of randomized controlled trials.Clinical rheumatology · 2021Pooled it
- Early urate-lowering therapy in gouty arthritis with acute flares: a double-blind placebo controlled clinical trial.European journal of medical research · 2023Trial
- Assessment of drug induced hyperuricemia and gout risk using the FDA adverse event reporting system.Scientific reports · 2025Article
- Korean guidelines for the management of gout.Journal of rheumatic diseases · 2023Review
- The Singapore Experience With Uncontrolled Gout: Unmet Needs in the Management of Patients.Cureus · 2023Review
- Relationship between hyperuricemia with deposition and sexual dysfunction in males and females.Journal of endocrinological investigation · 2022Review
- Association of urate deposition shown by ultrasound and frequent gout attacks.Zeitschrift fur Rheumatologie · 2021Article
Corrections and comments
- Erratum issuedErratum to: Does the initiation of urate-lowering treatment during an acute gout attack prolong the current episode and precipitate recurrent attacks: a systematic literature review.2017 · Le-Carratt, Jonathan [corrected to La-Crette, Jonathan]
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to systematically review the literature on effect of initiating urate-lowering treatment (ULT) during an acute attack of gout on duration of index attack and persistence on ULT. OVID (Medline), EMBASE and AMED were searched to identify randomized controlled trials (RCTs) of ULT initiation during acute gout attack published in English language. Two reviewers appraised the study quality and extracted data independently. Standardized mean difference (SMD) and relative risk (RR) were used to pool continuous and categorical data. Meta-analysis was carried out using STATA version 14. A total of 537 studies were selected. A total of 487 titles and abstracts were reviewed after removing duplicates. Three RCTs were identified. There was evidence from two high-quality studies that early initiation of allopurinol did not increase pain severity at days 10-15 [SMD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.