Evidence map›Paper›PMID 27761584›Full record

ArticleMolecular medicine (Cambridge, Mass.)2016

Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates with Progression of Human Myeloma.

Alberto L Horenstein, Valeria Quarona, Denise Toscani, Federica Costa, Antonella Chillemi, Vito Pistoia, Nicola Giuliani, Fabio Malavasi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 93 citations in OpenAlex.

  1. Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017
    Trial
  2. Review
  3. Review
  4. Dual blockade of adenosine AFrontiers in immunology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Prognostic value of nicotinamide adenine dinucleotide (NADJournal of gastrointestinal oncology · 2022
    Article
  18. Review
  19. Review
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alberto L HorensteinLaboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Torino 10126, Italy.
Valeria QuaronaLaboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Torino 10126, Italy.
Denise ToscaniMyeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma 43126, Italy.
Federica CostaMyeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma 43126, Italy.
Antonella ChillemiLaboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Torino 10126, Italy.
Vito PistoiaLaboratory of Oncology, Istituto Giannina Gaslini, Genova 16148, Italy.
Nicola GiulianiMyeloma Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma 43126, Italy.
Fabio MalavasiLaboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Torino 10126, Italy.
University of Turin · ITUniversity of Parma · ITIstituto Giannina Gaslini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing ATP and increasing NAD

Indexed as

adenosinebone nicheclinical stagingectoenzymesmyeloma

Identifiers

PMID27761584
PMCPMC5135080
OpenAlexW2537387853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.