ArticleeNeuro
The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed.
- Assistive algorithms influence neural representations in motor brain-computer interfaces.Nature communications · 2026Article
- Flexible reorientation of conserved neural dynamics underlies grasp control.bioRxiv : the preprint server for biology · 2026Article
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- Distinct sensorimotor encoding in tuft dendrites and somata associated with action, correction, and learning.bioRxiv : the preprint server for biology · 2026Article
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- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Premotor cortex uses a compositional neural geometry to plan words.bioRxiv : the preprint server for biology · 2026Article
- Encoding of speech modes and loudness in ventral precentral gyrus.Nature communications · 2026Article
- Enhanced reward coding and condition-independent dynamics in optogenetically identified corticostriatal neurons in monkeys.Nature communications · 2026Article
- Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.Nature communications · 2026Article
- Motor Cortical Computations Underlying Natural Dexterous Movement in Freely Flying Bats.bioRxiv : the preprint server for biology · 2026Article
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Restoration of temporal separability between beta and movement ensemble co-firing with motor recovery.Neuron · 2025Article
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- 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking.eLife · 2025Article
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Brain-computer interface control with artificial intelligence copilots.Nature machine intelligence · 2025Article
- Article
- Progressively shifting patterns of co-modulation among premotor cortex neurons carry dynamically similar signals during action execution and observation.bioRxiv : the preprint server for biology · 2025Article
64 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Neural activity in monkey motor cortex (M1) and dorsal premotor cortex (PMd) can reflect a chosen movement well before that movement begins. The pattern of neural activity then changes profoundly just before movement onset. We considered the prediction, derived from formal considerations, that the transition from preparation to movement might be accompanied by a large overall change in the neural state that reflects when movement is made rather than which movement is made. Specifically, we examined "components" of the population response: time-varying patterns of activity from which each neuron's response is approximately composed. Amid the response complexity of individual M1 and PMd neurons, we identified robust response components that were "condition-invariant": their magnitude and time course were nearly identical regardless of reach direction or path. These condition-invariant response components occupied dimensions orthogonal to those occupied by the "tuned" response components. The largest condition-invariant component was much larger than any of the tuned components; i.e., it explained more of the structure in individual-neuron responses. This condition-invariant response component underwent a rapid change before movement onset. The timing of that change predicted most of the trial-by-trial variance in reaction time. Thus, although individual M1 and PMd neurons essentially always reflected which movement was made, the largest component of the population response reflected movement timing rather than movement type.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.