Evidence map›Paper›PMID 27761409›Full record

ArticlePhotoacoustics2016

Multimodal optoacoustic and multiphoton microscopy of human carotid atheroma.

Markus Seeger, Angelos Karlas, Dominik Soliman, Jaroslav Pelisek, Vasilis Ntziachristos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. [Optoacoustic imaging-Applications and advancements of innovative imaging techniques].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Review
  10. Article
  11. Article
  12. Optoacoustic imaging in endocrinology and metabolism.Nature reviews. Endocrinology · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Markus SeegerChair for Biological Imaging, Technische Universität München, Munich, Germany; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Angelos KarlasChair for Biological Imaging, Technische Universität München, Munich, Germany; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany; Department of Cardiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Dominik SolimanChair for Biological Imaging, Technische Universität München, Munich, Germany; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Jaroslav PelisekDepartment of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Vasilis NtziachristosChair for Biological Imaging, Technische Universität München, Munich, Germany; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.
Institute of Biological and Medical ImagingKlinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotid artery atherosclerosis is a main cause of stroke. Understanding atherosclerosis biology is critical in the development of targeted prevention and treatment strategies. Consequently, there is demand for advanced tools investigating atheroma pathology. We consider hybrid optoacoustic and multiphoton microscopy for the integrated and complementary interrogation of plaque tissue constituents and their mutual interactions. Herein, we visualize human carotid plaque using a hybrid multimodal imaging system that combines optical resolution optoacoustic (photoacoustic) microscopy, second and third harmonic generation microscopy, and two-photon excitation fluorescence microscopy. Our data suggest more comprehensive insights in the pathophysiology of atheroma formation and destabilization, by enabling congruent visualization of structural and biological features critical for the atherosclerotic process and its acute complications, such as red blood cells and collagen.

Indexed as

BF, BrightfieldCAE, Carotid thrombendarterectomyCMR, Continuous multirecordCollagenDAQ, Data acquisitionFOV, Field of viewGM, Galvanometric mirrorsHE, Hemalaun-EosinHuman carotid atheromaIPH, Intraplaque hemorrhageLDL, Low density lipoproteinMAP, Maximum amplitude projectionMPM, Multiphoton microscopyMPOM, Multiphoton and optoacoustic microscopyMultimodal microscopyNLO, Non-linear opticalNon-linear optical microscopyOAM, Optoacoustic microscopyOptoacoustic microscopyPhotoacoustic microscopyPMT, Photo multiplier tubePSR, Picro-Sirius RedRBC, Red blood cellRed blood cellsROI, Region of interestSHG, Second harmonic generationSMC, Smooth muscle cellTHG, Third harmonic generationTPEF, Two-photon excitation fluorescence

Identifiers

PMID27761409
PMCPMC5063356
OpenAlexW2484641150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.