ArticleNeuroImage. Clinical2016
Interhemispheric connectivity in amyotrophic lateral sclerosis: A near-infrared spectroscopy and diffusion tensor imaging study.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions.Brain imaging and behavior · 2026Article
- Review
- White matter microstructural alterations and brain metabolism distributions in Parkinson's disease.Brain imaging and behavior · 2025Article
- Correlation analysis between excitability in the somatosensory cortex and structural changes in amyotrophic lateral sclerosis.Clinical neurophysiology practice · 2025Article
- Comparing different motion correction approaches for resting-state functional connectivity analysis with functional near-infrared spectroscopy data.Neurophotonics · 2024Article
- The Contribution of Functional Near-Infrared Spectroscopy (fNIRS) to the Study of Neurodegenerative Disorders: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Functional near-infrared spectroscopy as a potential objective evaluation technique in neurocognitive disorders after traumatic brain injury.Frontiers in psychiatry · 2022Article
- Multimodal fusion of EEG-fNIRS: a mutual information-based hybrid classification framework.Biomedical optics express · 2021Article
- Disease aggressiveness signatures of amyotrophic lateral sclerosis in white matter tracts revealed by the D50 disease progression model.Human brain mapping · 2021Article
- Electrical and Hemodynamic Neural Functions in People With ALS: An EEG-fNIRS Resting-State Study.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAim of the present study was to investigate potential impairment of non-motor areas in amyotrophic lateral sclerosis (ALS) using near-infrared spectroscopy (NIRS) and diffusion tensor imaging (DTI). In particular, we evaluated whether homotopic resting-state functional connectivity (rs-FC) of non-motor associated cortical areas correlates with clinical parameters and disease-specific degeneration of the corpus callosum (CC) in ALS. MATERIAL AND
methodsInterhemispheric homotopic rs-FC was assessed in 31 patients and 30 healthy controls (HCs) for 8 cortical sites, from prefrontal to occipital cortex, using NIRS. DTI was performed in a subgroup of 21 patients. All patients were evaluated for cognitive dysfunction in the executive, memory, and visuospatial domains.
resultsALS patients displayed an altered spatial pattern of correlation between homotopic rs-FC values when compared to HCs (
conclusionsThe present study further supports involvement of non-motor areas in ALS. Our results render homotopic rs-FC as assessed by NIRS a potential clinical marker for disease progression rate in ALS patients without executive dysfunction and a potential anatomical marker for ALS-specific degeneration of the CC and CSTs.
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