Evidence map›Paper›PMID 27761358›Full record

ArticleFEBS open bio2016

Stabilization of tryptophan hydroxylase 2 by l-phenylalanine-induced dimerization.

Kasper D Tidemand, Hans E M Christensen, Niclas Hoeck, Pernille Harris, Jane Boesen, Günther H Peters

Open access · goldAbstract read
In one paragraph

Article in FEBS open bio, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kasper D TidemandDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Hans E M ChristensenDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Niclas HoeckDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Pernille HarrisDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Jane BoesenDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Günther H PetersDepartment of Chemistry Technical University of Denmark Kongens Lyngby Denmark.
Technical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. Full-length TPH2 is poorly characterized due to low purification quantities caused by its inherent instability. Three truncated variants of human TPH2 (rc

Indexed as

analytical size exclusion chromatographydifferential scanning fluorimetryenzyme characterizationoligomerizationprotein purification

Identifiers

PMID27761358
PMCPMC5055035
OpenAlexW2474609557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.