Evidence map›Paper›PMID 27761306›Full record

ArticlePeerJ2016

Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis.

Sonja C Sawh, Santosh Deshpande, Sandy Jansen, Christopher J Reynaert, Philip M Jones

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04977817 (A Prospective/Retrospective Chart Review of the Effects of a Probiotic Dietary Supplement on Days of Total Parenteral Nutrition in Two Neonatal Intensive Care Units), which is not on this map. Cited by 73 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 12 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04977817 completednot on this mapstarted 2021, after this paper: background citation

A Prospective/Retrospective Chart Review of the Effects of a Probiotic Dietary Supplement on Days of Total Parenteral Nutrition in Two Neonatal Intensive Care Units

TypeobservationalSponsorPediatrixRan2021 to 2022Enrolled150ConditionsTotal Parenteral Nutrition, Necrotizing Enterocolitis of NewbornArmsSimilac Probiotic Tri-Blend
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 12 syntheses or guidelines pooled it, 133 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sonja C SawhDepartment of Pharmacy, London Health Sciences Centre, London, Ontario, Canada.
Santosh Deshpande *Department of Pharmacy, London Health Sciences Centre, London, Ontario, Canada.
Sandy Jansen *Department of Pharmacy, London Health Sciences Centre, London, Ontario, Canada.
Christopher J Reynaert *Department of Pharmacy, London Health Sciences Centre, London, Ontario, Canada.
Philip M Jones *Departments of Anesthesia & Perioperative Medicine and Epidemiology & Biostatistics, University of Western Ontario, London, Ontario, Canada.
London Health Sciences Centre · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextNecrotizing enterocolitis (NEC) is the most frequent gastrointestinal emergency in neonates. The microbiome of the preterm gut may regulate the integrity of the intestinal mucosa. Probiotics may positively contribute to mucosal integrity, potentially reducing the risk of NEC in neonates.

objectiveTo perform an updated systematic review and meta-analysis on the efficacy and safety of probiotics for the prevention of NEC in premature infants. DATA SOURCES: Structured searches were performed in: Medline, Embase, and the Cochrane Central Register of Controlled Trials (all via Ovid, from 2013 to January 2015). Clinical trial registries and electronically available conference materials were also searched. An updated search was conducted June 3, 2016. STUDY SELECTION: Randomized trials including infants less than 37 weeks gestational age or less than 2,500 g on probiotic vs. standard therapy. DATA EXTRACTION: Data extraction of the newly-identified trials with a double check of the previously-identified trials was performed using a standardized data collection tool.

resultsThirteen additional trials ( LIMITATIONS: Heterogeneity of organisms and dosing regimens studied prevent a species-specific treatment recommendation from being made.

conclusionsPreterm infants benefit from probiotics to prevent severe NEC and death.

Indexed as

BifidobacteriumEnterocolitisExtremely prematureInfantLactobacillusNecrotizing enterocolitisNewbornPrematureProbioticsSaccharomyces

Identifiers

PMID27761306
PMCPMC5068355
OpenAlexW2528175253

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.