Evidence map›Paper›PMID 27761214›Full record

ArticleInternational journal of preventive medicine2016

Antidepressant Activity of

V A Doss, Dharaniyambigai Kuberapandian

Open access · goldAbstract read
In one paragraph

Article in International journal of preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Evaluation of Anti-hypertrophic Potential ofIndian journal of clinical biochemistry : IJCB · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

V A DossDepartment of Biochemistry, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.
Dharaniyambigai KuberapandianDepartment of Biochemistry, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study is to develop a new animal model based on signaling pathways to understand the pathophysiology, therapy of depression, and to investigate the antidepressant activity of

methodsAnimal models of depression were raised by physical methods and administration of methyl isobutyl ketone (100 mg/kg b.w., i.p.,) and a protein tyrosine phosphatase inhibitor, sodium orthovanadate (30 mg/kg b.w., i.p.,) to young Wistar rats.

resultsHigh-performance thin-layer chromatography confirmed the presence of swertiamarin, a unique glycoside present in the

conclusionsThis study shows that sodium orthovanadate induces depression in animals and also establishes the antidepressant activity of

Indexed as

DepressionEnicostemma littorale Blumesodium orthovanadate

Identifiers

PMID27761214
PMCPMC5070033
OpenAlexW2524968801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.