Evidence map›Paper›PMID 27761079›Full record

ArticlePharmacognosy magazine2016

Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind

Shekhar Dethe, M Deepak, Amit Agarwal

Abstract read
In one paragraph

Article in Pharmacognosy magazine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shekhar DetheNatural Remedies R and D Centre No. 5B, Veerasandra, Bangalore, India.
M DeepakNatural Remedies R and D Centre No. 5B, Veerasandra, Bangalore, India.
Amit AgarwalNatural Remedies R and D Centre No. 5B, Veerasandra, Bangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveThe objective of this study was to understand the molecular mechanism of memory enhancing activity of BacoMind MATERIALS AND

methodsBM was screened

resultsBM was found to inhibit three enzymes; Catechol-O-methyl transferase (COMT), Prolyl endopeptidase (PEP), and Poly (ADP-ribose) polymerase (PARP). It also had an antagonistic effect on serotonin 6 and 2A (5-HT

conclusionBM was found to inhibit three enzymes namely, Catechol-O-methyl transferase (COMT), Prolyl endopeptidase (PEP), and Poly (ADP-ribose) polymerase (PARP). It also exhibited an antagonistic effect on 5-HT SUMMARY: This study was conducted to understand the molecular mechanism of memory enhancing activity of a standardized extract of

Indexed as

BacomindBacopa monniericognitionenzyme inhibitionlearning and memorymechanism of actionserotonin receptors

Identifiers

PMID27761079
PMCPMC5068128

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.