Evidence map›Paper›PMID 27760856›Full record

ArticleSLAS discovery : advancing life sciences R & D2017

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels.

Robyn T Rebbeck, Maram M Essawy, Florentin R Nitu, Benjamin D Grant, Gregory D Gillispie, David D Thomas, Donald M Bers, Razvan L Cornea

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Cyto-Genotoxic and Behavioral Effects of Flubendiamide inInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Synergistic FRET assays for drug discovery targeting RyR2 channels.Journal of molecular and cellular cardiology · 2022
    Article
  11. Article
  12. How Functional Genomics Can Keep Pace With VUS Identification.Frontiers in cardiovascular medicine · 2022
    Review
  13. Review
  14. Article
  15. Regulatory mechanisms of ryanodine receptor/CaJournal of muscle research and cell motility · 2021
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Robyn T Rebbeck1 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Maram M Essawy1 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Florentin R Nitu1 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Benjamin D Grant2 Fluorescence Innovations, Inc., Minneapolis, MN, USA.
Gregory D Gillispie2 Fluorescence Innovations, Inc., Minneapolis, MN, USA.
David D Thomas1 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Donald M Bers3 Department of Pharmacology, University of California, Davis, CA, USA.
Razvan L Cornea1 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USFluorescence Innovations (United States) · USUniversity of California, Davis · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Site-Directed Oxidative Modification of Muscle Protein Structural DynamicsR37AG026160 · NIA · UNIVERSITY OF MINNESOTA · PI THOMAS, DAVID D · 2011 to 2020
$4.5M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
Protein Oxidation, Structure, &Function in Aging MuscleR01AG026160 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THOMAS, DAVID D · 2004 to 2008
$2.2M
Live-Cell Fluorescence Lifetime FRET Assays for HTSR42DA037622 · NIDA · FLUORESCENCE INNOVATIONS, INC. · PI GILLISPIE, GREGORY DAVID · 2015 to 2016
$1.5M
NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL092097NIA NIH HHS R01 AG026160NIA NIH HHS R37 AG026160NIDA NIH HHS R42 DA037622
6 · The paper itself

Abstract

Using time-resolved fluorescence resonance energy transfer (FRET), we have developed and validated the first high-throughput screening (HTS) method to discover compounds that modulate an intracellular Ca

Indexed as

Calcium SignalingCalmodulinFluorescence Resonance Energy TransferHumansMuscle, SkeletalNervous System DiseasesProtein BindingRyanodineRyanodine Receptor Calcium Release ChannelTacrolimus Binding ProteinsCalmodulinRyanodineRyanodine Receptor Calcium Release Channeltacrolimus binding protein 1BTacrolimus Binding Proteinscalcium channelcalcium leakfluorescence lifetimeRyRsarco/endoplasmic reticulum

Identifiers

PMID27760856
PMCPMC5337111
OpenAlexW2533125922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.