Evidence map›Paper›PMID 27760755›Full record

ArticleAmerican journal of physiology. Cell physiology2016

Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels.

Cristina Matthewman, Tyne W Miller-Fleming, David M Miller, Laura Bianchi

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Effect of the protease plasmin onmicroPublication biology · 2021
    Article
  4. Article
  5. DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man.Advances in experimental medicine and biology · 2021
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cristina MatthewmanDepartment of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, Florida.
Tyne W Miller-FlemingNeuroscience Program, Vanderbilt University, Nashville, Tennessee.
David M MillerDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee; and.
Laura BianchiDepartment of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, Florida; lbianchi@med.miami.edu.
University of Miami · USVanderbilt University · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Molecular Genetics of Synaptic PlasticityR01NS106951 · NINDS · VANDERBILT UNIVERSITY · PI BIANCHI, LAURA, MILLER, DAVID M · 2018 to 2022
$2.2M
Molelcular determinants of synaptic plasticityR01NS081259 · NINDS · VANDERBILT UNIVERSITY · PI BIANCHI, LAURA, MILLER, DAVID M · 2013 to 2016
$1.5M
NICHD NIH HHS U54 HD083211NINDS NIH HHS R01 NS081259NINDS NIH HHS R01 NS106951
6 · The paper itself

Abstract

Hyperactivated DEG/ENaC channels cause neuronal death mediated by intracellular Ca

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumCell DeathCells, CulturedEpithelial Sodium ChannelsMembrane ProteinsOocytesPermeabilitySodiumSodium ChannelsXenopus laevisCaenorhabditis elegans ProteinsCalciumEpithelial Sodium ChannelsMembrane ProteinsSodiumSodium Channelscalcium permeabilityDEG/ENaC channelsneurotoxicity

Identifiers

PMID27760755
PMCPMC5206307
OpenAlexW2533903452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.