Evidence map›Paper›PMID 27760549›Full record

ArticleGenome biology2016

A new timepiece: an epigenetic mitotic clock.

Brock C Christensen, Karl T Kelsey

Abstract readComment
In one paragraph

Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Brock C ChristensenDepartment of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
Karl T KelseyDepartment of Epidemiology, Brown University, Providence, RI, 02912, USA. karl_kelsey@brown.edu.

Funding

Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7M
MicroRNA related genetic variation and head and neck cancerR01DE022772 · NIDCR · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2016
$2.7M
Prospective immune profiling using methylation markers and pancreatic cancer riskR01CA207110 · NCI · TUFTS UNIVERSITY BOSTON · PI KELSEY, KARL TIMOTHY, MICHAUD, DOMINIQUE S. · 2016 to 2018
$2.1M
Medical Research Council MC_UU_12019/1NCI NIH HHS R01 CA207110NIDCR NIH HHS R01 DE022772NIGMS NIH HHS P20 GM104416
6 · The paper itself

Abstract

A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.

Indexed as

EpigenomicsCell LineageCpG IslandsDNA MethylationGenome-Wide Association StudyHumansMitosis

Identifiers

PMID27760549
PMCPMC5072295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.