Evidence map›Paper›PMID 27760543›Full record

ArticleBMC public health2016

Risk factors for possible serious bacterial infection in a rural cohort of young infants in central India.

Marie E Wang, Archana B Patel, Nellie I Hansen, Lauren Arlington, Amber Prakash, Patricia L Hibberd

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01073475 (Global Network for Women's and Children's Health Research Maternal Newborn Health Registry), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01073475 recruitingnot on this map

Global Network for Women's and Children's Health Research Maternal Newborn Health Registry

TypeobservationalSponsorNICHD Global Network for Women's and Children's HealthRan2008 to 2030Enrolled950,000ConditionsPregnancy Outcome Trends in Low-resource Geographic AreasArmsThere is no intervention associated with the parent MNHR study. For the MNHR COVID sub-study, participants will be asked to provide a blood specimen at or near delivery.
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Marie E WangDivision of Infectious Diseases, Department of Medicine, Boston Children's Hospital, Boston, MA, USA. marie.wang@childrens.harvard.edu.
Archana B PatelLata Medical Research Foundation, Nagpur, Maharashtra, India.
Nellie I HansenRTI International, Research Triangle Park, NC, USA.
Lauren ArlingtonDepartment of Global Health, Boston University School of Public Health, Boston University, Boston, MA, USA.
Amber PrakashLata Medical Research Foundation, Nagpur, Maharashtra, India.
Patricia L HibberdDepartment of Global Health, Boston University School of Public Health, Boston University, Boston, MA, USA.
Boston University · USLata Medical Research Foundation · INBoston Children's Hospital · USRTI International · US

Funding

Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
Improving Quality of Care for the Treatment of Childhood PneumoniaU01HD058322 · NICHD · TUFTS UNIVERSITY BOSTON · PI HIBBERD, PATRICIA L · 2008 to 2012
$4.0M
Maternal and Child Health Benefits from Reducing Household Air PollutionU10HD078439 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HIBBERD, PATRICIA L · 2013 to 2017
$3.1M
Pediatric Infectious Diseases Research TrainingT32HD055148 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2018
$2.7M
Midcareer Investigator Award in Patient-Oriented Research (K24)K24AT003683 · NCCIH · TUFTS MEDICAL CENTER · PI HIBBERD, PATRICIA L · 2006 to 2015
$1.9M
NCCIH NIH HHS K24 AT003683NICHD NIH HHS T32 HD055148NICHD NIH HHS U01 HD058322NICHD NIH HHS U10 HD078439NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

backgroundPossible serious bacterial infection (PBSI) is a major cause of neonatal mortality worldwide. We studied risk factors for PSBI in a large rural population in central India where facility deliveries have increased as a result of a government financial assistance program.

methodsWe studied 37,379 pregnant women and their singleton live born infants with birth weight ≥ 1.5 kg from 20 rural primary health centers around Nagpur, India, using data from the 2010-13 population-based Maternal and Newborn Health Registry supported by NICHD's Global Network for Women's and Children's Health Research. Factors associated with PSBI were identified using multivariable Poisson regression.

resultsTwo thousand one hundred twenty-three infants (6 %) had PSBI. Risk factors for PSBI included nulliparity (RR 1.13, 95 % CI 1.03-1.23), parity > 2 (RR 1.30, 95 % CI 1.07-1.57) compared to parity 1-2, first antenatal care visit in the 2

conclusionInfants who are low birth weight, born to mothers who present late to antenatal care or receive antenatal corticosteroids, or born to nulliparous women or those with a parity > 2, could be targeted for interventions before and after delivery to improve early recognition of signs and symptoms of PSBI and prompt referral. There also appears to be a need for a renewed focus on promoting early initiation of breastfeeding following delivery in facilities.

trial registrationThis trial is registered at ClinicalTrials.gov ( NCT01073475 ).

Indexed as

Breast FeedingInfant, Low Birth WeightInfant MortalityParityPrenatal CareRural PopulationAdrenal Cortex HormonesAdultBacterial InfectionsBirth WeightDelivery, ObstetricFemaleHumansIndiaInfantInfant, NewbornAdrenal Cortex HormonesCohortIndiaPossible serious bacterial infectionYoung infant

Identifiers

PMID27760543
PMCPMC5070173
OpenAlexW2533167778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.