ArticleBMC anesthesiology2016
Outcome of cardiac surgery in patients with low preoperative ejection fraction.
Article in BMC anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674659 (The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Levosimendan vs. Milrinone in cardiac surgery: A GRADE-assessed systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Clinical Outcomes by Consolidation of Bone Marrow Stem Cell Therapy and Coronary Artery Bypass Graft in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-analysis.Cell transplantationPooled it
- Efficacy of Intraoperative Inhaled Nitric Oxide in Off-Pump Coronary Artery Bypass Grafting in Patients With Low Ejection Fraction.Circulation reports · 2026Article
- Outcomes and Predictors of In-Hospital Mortality After Isolated Coronary Artery Bypass Grafting in Patients with Severe Ischemic Cardiomyopathy: A Single-Centre Retrospective Analysis.Medical sciences (Basel, Switzerland) · 2026Article
- Development and external validation of a machine learning model for predicting severe immediate postoperative complications in adults undergoing cardiac surgery.BMC anesthesiology · 2026Article
- Echocardiographic factors associated with prolonged duration of inotrope therapy and ICU length of stay in a retrospective study of cardiac surgery patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- Association between Creatinine Trajectories and All-Cause Mortality in Elderly Patients after Cardiac Surgery: A Retrospective Cohort Study Based on MIMIC-IV.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
- Association between non-anemic iron deficiency and outcomes following off-pump coronary artery bypass surgery: a retrospective analysis.Korean journal of anesthesiology · 2025Article
- The association between intraoperative end-tidal carbon dioxide and prognosis in cardiac surgery patients: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study.Pediatric discovery · 2025Article
- Application of the comprehensive complication index and Clavien-Dindo complication classification in cardiac surgery: a retrospective study.BMC cardiovascular disorders · 2025Article
- Factors determining early mortality in ischemic mitral regurgitation surgery.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Comparison of scoring systems for bleeding in open cardiac surgery patients.Turkish journal of medical sciences · 2025Article
- Association Between the Red Blood Cell Distribution Width and 30-Day Mortality in Intensive Care Patients Undergoing Cardiac Surgery: A Retrospective Observational Study Based on the Medical Information Mart for Intensive Care-IV Database.Annals of laboratory medicine · 2024Observational
- Cardiac patients' surgery outcome and associated factors in Ethiopia: application of machine learning.BMC pediatrics · 2024Article
- Predicting outcomes in patients with low ejection fraction undergoing coronary artery bypass graft.International journal of cardiology. Heart & vasculature · 2024Article
- Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling.BMC medical informatics and decision making · 2024Article
- Preoperative sST2 levels relate to myocardial remodeling and cardiac function improvement after cardiac valve surgery.ESC heart failure · 2024Article
- Outcomes of coronary artery bypass surgery using modified del Nido cardioplegia in patients with poor ventricular function.Journal of cardiothoracic surgery · 2023Article
- Moderate Ischemic Mitral Regurgitation with Ejection Fraction <40% Undergoing Concomitant Mitral Valve Repair during Revascularization: A Single-Center Observational Study.Reviews in cardiovascular medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients undergoing cardiac surgery, a reduced preoperative left ventricular ejection fraction (LVEF) is common and is associated with a worse outcome. Available outcome data for these patients address specific surgical procedures, mainly coronary artery bypass graft (CABG). Aim of our study was to investigate perioperative outcome of surgery on patients with low pre-operative LVEF undergoing a broad range of cardiac surgical procedures.
methodsData from patients with pre-operative LVEF ≤40 % undergoing cardiac surgery at a university hospital were reviewed and analyzed. A subgroup analysis on patients with pre-operative LVEF ≤30 % was also performed.
resultsA total of 7313 patients underwent cardiac surgery during the study period. Out of these, 781 patients (11 %) had a pre-operative LVEF ≤40 % and were included in the analysis. Mean pre-operative LVEF was 33.9 ± 6.1 % and in 290 patients (37 %) LVEF was ≤30 %. The most frequently performed operation was CABG (31 % of procedures), followed by mitral valve surgery (22 %) and aortic valve surgery (19 %). Overall perioperative mortality was 5.6 %. Mitral valve surgery was more frequent among patients who did not survive, while survivors underwent more frequently CABG. Post-operative myocardial infarction occurred in 19 (2.4 %) of patients, low cardiac output syndrome in 271 (35 %). Acute kidney injury occurred in 195 (25 %) of patients. Duration of mechanical ventilation was 18 (12-48) hours. Incidence of complications was higher in patients with LVEF ≤30 %. Stepwise multivariate analysis identified chronic obstructive pulmonary disease, pre-operative insertion of intra-aortic balloon pump, and pre-operative need for inotropes as independent predictors of mortality among patients with LVEF ≤40 %.
conclusionsWe confirmed that patients with low pre-operative LVEF undergoing cardiac surgery are at higher risk of post-operative complications. Cardiac surgery can be performed with acceptable mortality rates; however, mitral valve surgery, was found to be associated with higher mortality rates in this population. Accurate selection of patients, risk/benefit evaluation, and planning of surgical and anesthesiological management are mandatory to improve outcome.
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