Evidence map›Paper›PMID 27760377›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2017

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.

K R Vogel, G R Ainslie, E E W Jansen, G S Salomons, K M Gibson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

K R VogelDivision of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA.
G R AinslieDivision of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA.
E E W JansenMetabolic Unit, Department of Clinical Chemistry, VU University Medical Center, Neuroscience Campus, Amsterdam, The Netherlands.
G S SalomonsMetabolic Unit, Department of Clinical Chemistry, VU University Medical Center, Neuroscience Campus, Amsterdam, The Netherlands.
K M GibsonDivision of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA, USA. Electronic address: mike.gibson@wsu.edu.
Washington State University Spokane · USAmsterdam Neuroscience · NL

Funding

Rapalog Therapy in Heritable and Vigabatrin-Induced GABA Metabolic DisordersR01EY027476 · NEI · WASHINGTON STATE UNIVERSITY · PI GIBSON, K MICHAEL · 2017 to 2020
$1.7M
Placebo-Controlled Phase II Trial of SGS742 (GABAB receptor antagonist) in Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency, a DisorderR01NS082286 · NINDS · WASHINGTON STATE UNIVERSITY · PI GIBSON, K MICHAEL · 2013 to 2016
$877k
Therapeutics of mTOR Signaling in Succinic Semialdehyde Dehydrogenase DeficiencyR21NS085369 · NINDS · WASHINGTON STATE UNIVERSITY · PI GIBSON, K MICHAEL · 2014 to 2015
$432k
NEI NIH HHS R01 EY027476NINDS NIH HHS R01 NS082286NINDS NIH HHS R21 NS085369
6 · The paper itself

Abstract

Aldehyde dehydrogenase 5a1-deficient (aldh5a1

Indexed as

Gene DeletionAmino Acid Metabolism, Inborn ErrorsAnimalsDevelopmental DisabilitiesDisease Models, AnimalFemalegamma-Aminobutyric AcidGlutathioneMaleMiceMice, Inbred C57BLNaphthyridinesOxidative StressSignal TransductionSuccinate-Semialdehyde DehydrogenaseTOR Serine-Threonine Kinases1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-oneAldh5a1 protein, mousegamma-Aminobutyric AcidGlutathionemTOR protein, mouseNaphthyridinesSuccinate-Semialdehyde DehydrogenaseTOR Serine-Threonine KinasesGABAmTOROxidative stressSuccinic semialdehyde dehydrogenase deficiencyTorin 1Torin 2

Identifiers

PMID27760377
PMCPMC5154833
OpenAlexW2535654594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.