ArticleImmunity2016
The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance.
Open access · greenAbstract read
In one paragraph
Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Defective inducible T cell costimulator signalling drives neuropilin-1Experimental & molecular medicine · 2026Article
- Whole transcriptome landscape in HAPE under the stress of environment at high altitudes: new insights into the mechanisms of hypobaric hypoxia tolerance.Frontiers in immunology · 2024Article
- Efficient gene deletion of Integrin alpha 4 in primary mouse CD4 T cells using CRISPR RNA pair-mediated fragmentation.Frontiers in immunology · 2024Article
- ICAM-1 mediated cell-cell adhesion exerts dual roles on human B cell differentiation and IgG production.iScience · 2023Article
- Advances in the pathogenesis and therapeutic strategies of angioimmunoblastic T-cell lymphoma.Clinical and experimental medicine · 2023Review
- Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion.Trends in immunology · 2023Review
- Conserved stromal-immune cell circuits secure B cell homeostasis and function.Nature immunology · 2023Article
- Article
- Cell adhesion molecules and immunotherapy in advanced non-small cell lung cancer: Current process and potential application.Frontiers in oncology · 2023Review
- A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.Science signaling · 2022Article
- T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022Review
- CCR7-mediated T follicular helper cell differentiation is associated with the pathogenesis and immune microenvironment of spinal cord injury-induced immune deficiency syndrome.Frontiers in neuroscience · 2022Article
- Targeting T Follicular Helper Cells to Control Humoral Allogeneic Immunity.Transplantation · 2021Review
- Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis.The Journal of clinical investigation · 2021Article
- The Tumor Microenvironment in Follicular Lymphoma: Its Pro-Malignancy Role with Therapeutic Potential.International journal of molecular sciences · 2021Review
- Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Review
- BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor.Frontiers in pharmacology · 2021Article
- Stepwise Tfh cell differentiation revisited: new advances and long-standing questions.Faculty reviews · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Alexandre P MeliDepartment of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada.
Ghislaine FontésDepartment of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada.
Danielle T AveryThe Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Scott A LeddonDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.
Mifong TamDepartment of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada.
Michael ElliotSydney Head and Neck Cancer Institute, Camperdown, NSW 2050, Australia.
Andre Ballesteros-TatoDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jim MillerDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.
Mary M StevensonDepartment of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada.
Deborah J FowellDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA.
Stuart G TangyeThe Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Irah L KingDepartment of Microbiology and Immunology, Microbiome and Disease Tolerance Centre, McGill University, Montreal, Quebec H3A 2B4, Canada. Electronic address: irah.king@mcgill.ca.
McGill University · CAUniversity of Rochester Medical Center · USGarvan Institute of Medical Research · AUCancer Institute of New South Wales · AUMcGill University Health Centre · CAUniversity of Alabama at Birmingham · US
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9MTissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Deborah J Fowell · 2014 to 2026
$26.0MTraining Program in Oral ScienceT90DE021985 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE, YULE, DAVID I · 2011 to 2021
$5.6MCIHR MOP-130579NCI NIH HHS P30 CA013148NIAID NIH HHS P01 AI102851NIDCR NIH HHS T90 DE021985
Abstract
T follicular helper (Tfh) cells are a CD4
Indexed as
AnimalsCell DifferentiationCells, CulturedGerminal CenterHumansImmunity, HumoralLymphocyte ActivationLymphocyte Function-Associated Antigen-1MiceMice, Inbred C57BLProto-Oncogene Proteins c-bcl-6T-Lymphocytes, Helper-InducerLymphocyte Function-Associated Antigen-1Proto-Oncogene Proteins c-bcl-6
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.