ArticleImmunity2016
Macrophages' Choice: Take It In or Keep It Out.
Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- A granulin-positive macrophage subtype in mycobacterial granulomas alleviates tissue damage by limiting excessive inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A portrait of 2 nematodes in liver of their paratenic fish hosts, illustrating different immunological approaches.Parasitology · 2025Article
- Serine protease Rv2569c facilitates transmission of Mycobacterium tuberculosis via disrupting the epithelial barrier by cleaving E-cadherin.PLoS pathogens · 2024Article
- Teleost innate immunity, an intricate game between immune cells and parasites of fish organs: who wins, who loses.Frontiers in immunology · 2023Review
- Granulomatous manifestations associated with COVID19 infection: Is there a link between these two diseases?Autoimmunity reviews · 2021Article
- Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection.Frontiers in immunology · 2021Review
- Granulomas in parasitic diseases: the good and the bad.Parasitology research · 2020Review
- Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.American journal of respiratory cell and molecular biology · 2020Review
- Asap1 Affects the Susceptibility of Zebrafish toFrontiers in cellular and infection microbiology · 2020Article
- Intestinal Lamina Propria CD4Infection and immunity · 2018Article
- Angiotensin-converting enzyme in innate and adaptive immunity.Nature reviews. Nephrology · 2018Review
- Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis.Frontiers in microbiology · 2018Review
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tuberculosis, some macrophages in granulomas assume an epitheloid appearance. Using the Mycobacterium marinum-zebrafish model, Cronan et al. (2016) now show that granuloma macrophages undergo reprograming events involving E-cadherin-dependent formation of epithelial-like cell-cell junctions. Interference with the function of E-cadherin in macrophages disorganized the granulomas and protected the fish, introducing new ideas and questions about macrophage function and granulomatous diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.