Evidence map›Paper›PMID 27760304›Full record

ReviewLife sciences2016

Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking.

Sayak Bhattacharya, Kevin E McElhanon, Liubov V Gushchina, Noah Weisleder

Open access · greenAbstract readReview
In one paragraph

Review in Life sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Internalization of benzylisoquinoline alkaloids by resting and activated bone marrow-derived mast cells utilizes energy-dependent mechanisms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. An Immunological Approach to the Biocompatibility of Mesoporous SiOInternational journal of molecular sciences · 2020
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sayak BhattacharyaDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
Kevin E McElhanonDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
Liubov V GushchinaDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.
Noah WeislederDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States. Electronic address: noah.weisleder@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

Targeting Membrane Repair in Muscular DystrophyR01AR063084 · NIAMS · OHIO STATE UNIVERSITY · PI WEISLEDER, NOAH · 2012 to 2016
$1.7M
NIAMS NIH HHS R01 AR063084
6 · The paper itself

Abstract

Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.

Indexed as

EndocytosisExocytosisSignal TransductionAnimalsHumansPhosphatidylinositol 3-KinasesPhosphotransferases (Alcohol Group Acceptor)Proto-Oncogene Proteins c-aktPhosphatidylinositol 3-Kinasesphosphatidylinositol 4,5-biphosphate kinasePhosphotransferases (Alcohol Group Acceptor)Proto-Oncogene Proteins c-aktAKTCaveolaeClathrinEndocytosisExocytosisMembrane traffickingPhosphatidylinositol-4,5-bisphosphate 3-kinasePI3KProtein kinase B

Identifiers

PMID27760304
PMCPMC5204450
OpenAlexW2537147719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.