Evidence map›Paper›PMID 27760279›Full record

ArticleThe FEBS journal2016

Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.

Somasundaram Ramasamy, Mohammad Mahfuzul Haque, Mahinda Gangoda, Dennis J Stuehr

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Somasundaram RamasamyDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, OH, USA.
Mohammad Mahfuzul HaqueDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, OH, USA.
Mahinda GangodaDepartment of Chemistry and Biochemistry, Kent State University, OH, USA.
Dennis J StuehrDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, OH, USA.
Cleveland Clinic Lerner College of Medicine · USKent State University · US

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
CONTROL MECHANISMS OF THE NITRIC OXIDE SYNTHASESR01GM051491 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI STUEHR, DENNIS J · 1994 to 2016
$5.1M
NHLBI NIH HHS P01 HL076491NIGMS NIH HHS R01 GM051491
6 · The paper itself

Abstract

The nitric oxide synthases (NOS) catalyze a two-step oxidation of l-arginine (Arg) to generate NO. In the first step, O

Indexed as

ElectronsAnimalsArginineBiocatalysisBiopterinsElectron Spin Resonance SpectroscopyElectron TransportFree RadicalsHemeKineticsModels, MolecularMolecular StructureMutationNitric Oxide Synthase Type IOxidation-ReductionProtein BindingArginineBiopterinsFree RadicalsHemeNitric Oxide Synthase Type Isapropterinbiopterinelectron paramagnetic resonanceelectron transferflavoproteinfreeze quenchheme porphyrinheme reductionneuronal NOS

Identifiers

PMID27760279
PMCPMC5387691
OpenAlexW2533432700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.