ArticleMagnetic resonance in medicine2017
Accurate MR thermometry by hyperpolarized
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- RF Heating Effects in CEST NMR with HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarizedCommunications medicine · 2023Article
- Longitudinal nuclear spin relaxation ofMagnetic resonance in medicine · 2022Article
- An open-source, low-cost NMR spectrometer operating in the mT field regime.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Comparison of single breath hyperpolarizedMagnetic resonance in medicine · 2021Article
- Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.The Journal of biological chemistry · 2020Review
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Direct detection of brown adipose tissue thermogenesis in UCP1-/- mice by hyperpolarizedScientific reports · 2019Article
- Calibration of methylene-referenced lipid-dissolved xenon frequency for absolute MR temperature measurements.Magnetic resonance in medicine · 2019Article
- Multinuclear absolute magnetic resonance thermometry.Communications physics · 2019Article
- Simple and robust referencing system enables identification of dissolved-phase xenon spectral frequencies.Magnetic resonance in medicine · 2018Article
- Correlation distance dependence of the resonance frequency of intermolecular zero quantum coherences and its implication for MR thermometry.Magnetic resonance in medicine · 2018Article
- Depolarization of nuclear spin polarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo investigate the temperature dependence of the resonance frequency of lipid-dissolved xenon (LDX) and to assess the accuracy of LDX-based MR thermometry.
methodsThe chemical shift temperature dependence of water protons, methylene protons, and LDX was measured from samples containing tissues with varying fat contents using a high-resolution NMR spectrometer. LDX results were then used to acquire relative and absolute temperature maps in vivo and the results were compared with PRF-based MR thermometry.
resultsThe temperature dependence of proton resonance frequency (PRF) is strongly affected by the specific distribution of water and fat. A redistribution of water and fat compartments can reduce the apparent temperature dependence of the water chemical shift from -0.01 ppm/°C to -0.006 ppm, whereas the LDX chemical shift shows a consistent temperature dependence of -0.21 ppm/°C. The use of the methylene protons resonance frequency as internal reference improves the accuracy of LDX-based MR thermometry, but degrades that of PRF-based MR thermometry, as microscopic susceptibility gradients affected lipid and water spins differently.
conclusionThe LDX resonance frequency, with its higher temperature dependence, provides more accurate and precise temperature measurements, both in vitro and in vivo. More importantly, the resonance frequency of nearby methylene protons can be used to extract absolute temperature information. Magn Reson Med 78:1070-1079, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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