ArticleAlcoholism, clinical and experimental research2016
Impairments in Component Processes of Executive Function and Episodic Memory in Alcoholism, HIV Infection, and HIV Infection with Alcoholism Comorbidity.
Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- HIV-associated executive dysfunction in the era of modern antiretroviral therapy: A systematic review and meta-analysis.Journal of clinical and experimental neuropsychology · 2018Pooled it
- Digital language measures capture episodic memory disruptions in people with human immunodeficiency virus: A machine learning study.The Clinical neuropsychologist · 2026Article
- Executive Function and Adherence in Children and Adolescents Living With HIV: Evidence From the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study.Journal of child neurology · 2026Article
- Cognitive Flexibility and Inhibition Deficits in HIV and Cocaine Dependence: Evidence from Stroop and Trail Making Tests.Viruses · 2026Article
- Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Moderate-to-severe cognitive impairment is associated with both recent and chronic alcohol misuse in people with HIV: The New Orleans alcohol use in HIV (NOAH) study.Alcohol, clinical & experimental research · 2024Article
- Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications.Journal of the American Geriatrics Society · 2023Article
- Episodic memory deficit in HIV infection: common phenotype with Parkinson's disease, different neural substrates.Brain structure & function · 2023Article
- Risky Decision-Making in Adults with Alcohol Use Disorder-A Systematic and Meta-Analytic Review.Journal of clinical medicine · 2023Review
- A prospective study revealing a compounded burden of COVID-19, sex, and clinical diagnosis of alcohol use disorder and HIV infection on quality of life, anxiety, and alcohol use.Journal of psychiatric research · 2022Article
- Binge Drinking Relates to Worse Neurocognitive Functioning Among Adults Aging with HIV.Journal of the International Neuropsychological Society : JINS · 2022Article
- Effects of unhealthy alcohol use on brain morphometry and neurocognitive function among people with HIV.Journal of neurovirology · 2022Article
- Reduced Working Memory is Associated with Heavier Alcohol Consumption History, Role Impairment and Executive Function Difficulties.AIDS and behavior · 2021Article
- Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.Journal of neuropsychology · 2021Article
- Neuroimaging and Cognitive Evidence for Combined HIV-Alcohol Effects on the Central Nervous System: A Review.Alcoholism, clinical and experimental research · 2021Article
- Alcohol consumption and neurocognitive deficits in people with well-treated HIV in Switzerland.PloS one · 2021Article
- Pathophysiological Consequences of At-Risk Alcohol Use; Implications for Comorbidity Risk in Persons Living With Human Immunodeficiency Virus.Frontiers in physiology · 2021Review
- Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity.AIDS (London, England) · 2020Article
- Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.Neuropsychology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExecutive functioning and episodic memory impairment occur in HIV infection (HIV) and chronic alcoholism (ALC). Comorbidity of these conditions (HIV + ALC) is prevalent and heightens risk of vulnerability to separate and compounded deficits. Age and disease-related variables can also serve as mediators of cognitive impairment and should be considered, given the extended longevity of HIV-infected individuals in this era of improved pharmacological therapy.
methodsHIV, ALC, HIV + ALC, and normal controls (NC) were administered traditional and computerized tests of executive function and episodic memory. Test scores were expressed as age- and education-corrected Z-scores; selective tests were averaged to compute Executive Function and Episodic Memory Composite scores. Efficiency scores were calculated for tests with accuracy and response times.
resultsHIV, ALC, and HIV + ALC had lower scores than NC on Executive Function and Episodic Memory Composites, with HIV + ALC even lower than ALC and HIV on the Episodic Memory Composite. Impairments in planning and free recall of visuospatial material were observed in ALC, whereas impairments in psychomotor speed, sequencing, narrative free recall, and pattern recognition were observed in HIV. Lower decision-making efficiency scores than NC occurred in all 3 clinical groups. In ALC, age and lifetime alcohol consumption were each unique predictors of Executive Function and Episodic Memory Composite scores. In HIV + ALC, age was a unique predictor of Episodic Memory Composite score.
conclusionsDisease-specific and disease-overlapping patterns of impairment in HIV, ALC, and HIV + ALC have implications regarding brain systems disrupted by each disease and clinical ramifications regarding the complexities and compounded damping of cognitive functioning associated with dual diagnosis that may be exacerbated with aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.