Evidence map›Paper›PMID 27759563›Full record

ArticleeLife2016

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.

Marie-Julie Nokin, Florence Durieux, Paul Peixoto, Barbara Chiavarina, Olivier Peulen, Arnaud Blomme, Andrei Turtoi, Brunella Costanza, Nicolas Smargiasso, Dominique Baiwir and 15 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 127 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Non-Enzymatic MGO-Glycation of SRSF2 Drives RNA Mis-Splicing.Journal of the American Chemical Society · 2026
    Article
  8. Article
  9. Glyoxalase 1 is a proadipogenic gene.The Journal of biological chemistry · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Dual roles of methylglyoxal in cancer.Frontiers in oncology · 2025
    Review
  17. Review
  18. Review
  19. Protein Haptenation and Its Role in Allergy.Chemical research in toxicology · 2024
    Review
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 7 institutions in 7 countries.

Marie-Julie NokinMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Florence DurieuxMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Paul PeixotoMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Barbara ChiavarinaMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Olivier PeulenMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Arnaud BlommeMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Andrei TurtoiMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Brunella CostanzaMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Nicolas SmargiassoMass Spectrometry Laboratory, GIGA-Systems Biology and Chemical Biology, University of Liège, Liège, Belgium.
Dominique BaiwirGIGA Proteomic Facility, University of Liège, Liège, Belgium.
Jean L ScheijenLaboratory for Metabolism and Vascular Medicine, Department of Internal Medicine, Maastricht University, Maastricht, Netherlands.
Casper G SchalkwijkLaboratory for Metabolism and Vascular Medicine, Department of Internal Medicine, Maastricht University, Maastricht, Netherlands.
Justine LeendersLaboratory of Medicinal Chemistry - CIRM, University of Liège, Liège, Belgium.
Pascal De TullioLaboratory of Medicinal Chemistry - CIRM, University of Liège, Liège, Belgium.
Elettra BianchiDepartment of Pathology, CHU, University of Liège, Liège, Belgium.
Marc ThiryLaboratory of Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium.
Koji UchidaLaboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, University of Nagoya, Nagoya, Japan.
David A SpiegelDepartment of Chemistry, Yale University, New Haven, United States.
James R CochraneSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia.ORCID http://orcid.org/0000-0002-8796-2143
Craig A HuttonSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia.
Edwin De PauwMass Spectrometry Laboratory, GIGA-Systems Biology and Chemical Biology, University of Liège, Liège, Belgium.
Philippe DelvenneDepartment of Pathology, CHU, University of Liège, Liège, Belgium.
Dominique BelpommeAssociation for Research and Treatments Against Cancer, Paris, France.
Vincent CastronovoMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
Akeila BellahcèneMetastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.
University of Liège · BEBiotechnology Institute · USCardiovascular Institute Hospital · JPItalian Association for Cancer Research · ITMaastricht University · NLNagoya University · JPYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little is known regarding the impact of MG-mediated carbonyl stress on tumor progression. Breast tumors with MG stress presented with high nuclear YAP, a key transcriptional co-activator regulating tumor growth and invasion. Elevated MG levels resulted in sustained YAP nuclear localization/activity that could be reverted using Carnosine, a scavenger for MG. MG treatment affected Hsp90 chaperone activity and decreased its binding to LATS1, a key kinase of the Hippo pathway. Cancer cells with high MG stress showed enhanced growth and metastatic potential in vivo. These findings reinforce the cumulative evidence pointing to hyperglycemia as a risk factor for cancer incidence and bring renewed interest in MG scavengers for cancer treatment.

Indexed as

GlycolysisNeoplasm MetastasisAdaptor Proteins, Signal TransducingAerobiosisBreast NeoplasmsCell Line, TumorCell ProliferationGlycation End Products, AdvancedGlycosylationHSP90 Heat-Shock ProteinsHumansPhosphoproteinsProtein Processing, Post-TranslationalPyruvaldehydeTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingGlycation End Products, AdvancedHSP90 Heat-Shock ProteinsPhosphoproteinsPyruvaldehydeTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsbreast cancercancer biologycarbonyl stresscell biologychickenglyoxalase 1humanLATS1methylglyoxalmouseYAP

Identifiers

PMID27759563
PMCPMC5081250
OpenAlexW2534350753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.