Evidence map›Paper›PMID 27759468›Full record

ArticleActa orthopaedica2017

Heart failure after conventional metal-on-metal hip replacements.

Marianne H Gillam, Nicole L Pratt, Maria C S Inacio, Elizabeth E Roughead, Sepehr Shakib, Stephen J Nicholls, Stephen E Graves

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Acta orthopaedica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marianne H Gillama School of Pharmacy and Medical Sciences , The Quality Use of Medicines and Pharmacy Research Centre, University of South Australia.
Nicole L Pratta School of Pharmacy and Medical Sciences , The Quality Use of Medicines and Pharmacy Research Centre, University of South Australia.
Maria C S Inacioa School of Pharmacy and Medical Sciences , The Quality Use of Medicines and Pharmacy Research Centre, University of South Australia.
Elizabeth E Rougheada School of Pharmacy and Medical Sciences , The Quality Use of Medicines and Pharmacy Research Centre, University of South Australia.
Sepehr Shakibb Department of Clinical Pharmacology , School of Medicine, University of Adelaide.
Stephen J Nichollsc Department of Medicine , University of Adelaide and South Australian Health and Medical Research Institute, University of Adelaide.
Stephen E Gravesd Flinders University School of Medicine, Flinders University, Adelaide and Australian Orthopaedic Association National Joint Replacement Registry , Adelaide , Australia.
University of South Australia · AUSouth Australian Health and Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose - It is unclear whether metal particles and ions produced by mechanical wear and corrosion of hip prostheses with metal-on-metal (MoM) bearings have systemic adverse effects on health. We compared the risk of heart failure in patients with conventional MoM total hip arthroplasty (THA) and in those with metal-on-polyethylene (MoP) THA. Patients and methods - We conducted a retrospective cohort study using data from the Australian Government Department of Veterans' Affairs health claims database on patients who received conventional THA for osteoarthritis between 2004 and 2012. The MoM THAs were classified into groups: Articular Surface Replacement (ASR) XL Acetabular System, other large-head (LH) (> 32 mm) MoM, and small-head (SH) (≤ 32 mm) MoM. The primary outcome was hospitalization for heart failure after THA. Results - 4,019 patients with no history of heart failure were included (56% women). Men with an ASR XL THA had a higher rate of hospitalization for heart failure than men with MoP THA (hazard ratio (HR) = 3.2, 95% CI: 1.6-6.5). No statistically significant difference in the rate of heart failure was found with the other LH MoM or SH MoM compared to MoP in men. There was no statistically significant difference in heart failure rate between exposure groups in women. Interpretation - An association between ASR XL and hospitalization for heart failure was found in men. While causality between ASR XL and heart failure could not be established in this study, it highlights an urgent need for further studies to investigate the possibility of systemic effects associated with MoM THA.

Indexed as

RegistriesAgedAged, 80 and overArthroplasty, Replacement, HipAustraliaFemaleFollow-Up StudiesHeart FailureHip ProsthesisHumansIncidenceMaleMetal-on-Metal Joint ProsthesesProsthesis DesignProsthesis FailureRetrospective Studies

Identifiers

PMID27759468
PMCPMC5251259
OpenAlexW2544969099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.