ReviewChemical reviews2017
Fighting Cancer with Corroles.
Review in Chemical reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- PDT evaluation of gallium based 3G photosensitizers against triple negative breast cancer.Molecular diversity · 2026Article
- Next generation protein-corrole bio-assemblies provide effective tumoricidal treatment in a metastatic triple-negative breast cancer model.bioRxiv : the preprint server for biology · 2026Article
- Probing into the binding mechanism of phosphorus(V)-corrole with hemoglobin using photophysical and computational approach.Scientific reports · 2026Article
- Impact of Substitution Position on the Excited-State Dynamics and Nonlinear Optical Properties of Tetraphenylethylene-Corroles.Chemistry, an Asian journal · 2026Article
- Rhenium-Selenido Corroles: Reflections on 5d Metalloporphyrins and Metallocorroles as Triplet Emitters and Photosensitizers.Inorganic chemistry · 2025Article
- The role of corroles in modern cancer therapy: innovation and prospects.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- The role of corroles in modern cancer therapy: innovation and prospects.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Inverse Photoemission Spectroscopy of Coinage Metal Corroles: Comparison with Solution-Phase Electrochemistry.ACS organic & inorganic Au · 2024Article
- Gold Tripyrrindione: Redox Chemistry and Reactivity with Dichloromethane.Inorganic chemistry · 2024Article
- Surprising Route to a Monoazaporphyrin and Full Characterization of Its Complexes with Five Different 3d Metals.Inorganic chemistry · 2024Article
- Matrix Selection Strategies for MALDI-TOF MS/MS Characterization of Cyclic Tetrapyrroles in Blood and Food Samples.Molecules (Basel, Switzerland) · 2024Article
- Influence of Fluorinated Substituents on the Near-Infrared Phosphorescence of 5d Metallocorroles.ACS organic & inorganic Au · 2023Article
- Synthesis of N-, O-, and S-heterocycles from aryl/alkyl alkynyl aldehydes.RSC advances · 2023Review
- Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles.Molecules (Basel, Switzerland) · 2023Article
- Tuning the Molecular Structure of Corroles to Enhance the Antibacterial Photosensitizing Activity.Pharmaceutics · 2023Article
- Phenol- and resorcinol-appended metallocorroles and their derivatization with fluorous tags.Scientific reports · 2022Article
- Reaction of Corroles with Sarcosine and Paraformaldehyde: A New Facet of Corrole Chemistry.International journal of molecular sciences · 2022Article
- Fluorine Atoms on CInternational journal of molecular sciences · 2022Article
- Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis.Journal of nanobiotechnology · 2022Article
- Can Corrole Dimers Be Good Photosensitizers to Kill Bacteria?Microorganisms · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Corroles are exceptionally promising platforms for the development of agents for simultaneous cancer-targeting imaging and therapy. Depending on the element chelated by the corrole, these theranostic agents may be tuned primarily for diagnostic or therapeutic function. Versatile synthetic methodologies allow for the preparation of amphipolar derivatives, which form stable noncovalent conjugates with targeting biomolecules. These conjugates can be engineered for imaging and targeting as well as therapeutic function within one theranostic assembly. In this review, we begin with a brief outline of corrole chemistry that has been uniquely useful in designing corrole-based anticancer agents. Then we turn attention to the early literature regarding corrole anticancer activity, which commenced one year after the first scalable synthesis was reported (1999-2000). In 2001, a major advance was made with the introduction of negatively charged corroles, as these molecules, being amphipolar, form stable conjugates with many proteins. More recently, both cellular uptake and intracellular trafficking of metallocorroles have been documented in experimental investigations employing advanced optical spectroscopic as well as magnetic resonance imaging techniques. Key results from work on both cellular and animal models are reviewed, with emphasis on those that have shed new light on the mechanisms associated with anticancer activity. In closing, we predict a very bright future for corrole anticancer research, as it is experiencing exponential growth, taking full advantage of recently developed imaging and therapeutic modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.