SynthesisJournal of clinical hypertension (Greenwich, Conn.)2016
Proportion of Patients With Hypertension Resolution Following Adrenalectomy for Primary Aldosteronism: A Systematic Review and Meta-Analysis.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assessment of performance of stratum-specific likelihood ratios of the aldosteronoma resolution score for predicting hypertension cure after adrenalectomy for primary aldosteronism: a systematic review and meta-analysis.Journal of human hypertension · 2023Pooled it
- Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis.BMC endocrine disorders · 2017Pooled it
- Proportion of Patients With Hypertension Resolution Following Adrenalectomy for Primary Aldosteronism: A Systematic Review and Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2016Pooled it
- Thirty-six-month results of laparoscopic-based renal denervation plus unilateral laparoscopic adrenalectomy for the treatment of patients with resistant hypertension caused by unilateral aldosterone-producing adenoma.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- ASO Author Reflections: From Polypharmacy to Procedure-Defining Value in the Management of Primary Aldosteronism.Annals of surgical oncology · 2026Article
- Fewer Pills, Lower Bills: Antihypertensive and Cost Outcomes of Adrenalectomy in Primary Aldosteronism.Annals of surgical oncology · 2026Article
- Factors affecting clinical outcomes of minimally invasive adrenalectomy for unilateral primary aldosteronism: a single-center retrospective cohort study.Gland surgery · 2025Article
- The prognostic value of CXCR4 PET/CT imaging in unilateral primary aldosteronism patients after adrenalectomy.EJNMMI research · 2025Article
- Discordance between adrenal vein sampling and imaging: the role of unilateral cortisol excess.European journal of endocrinology · 2025Article
- Diagnosis and management of adrenal incidentaloma: use of clinical judgment and evidence in dialog with the patient.Surgery today · 2024Review
- Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish Hypertension Society.Journal of human hypertension · 2024Review
- Predictors of successful outcome after adrenalectomy for unilateral primary aldosteronism.Frontiers in endocrinology · 2023Article
- Article
- Clinical cure vs a novel trifecta system for evaluating long-term outcomes of minimally-invasive partial or total adrenalectomy for unilateral primary aldosteronism: results of a multicentric series.Central European journal of urology · 2022Article
- Urine steroid profile as a new promising tool for the evaluation of adrenal tumors. Literature review.Endocrine · 2021Review
- Adrenal artery ablation for primary aldosteronism without apparent aldosteronoma: An efficacy and safety, proof-of-principle trial.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism.Journal of human hypertension · 2020Article
- Predictors of Clinical Success After Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort.Journal of the Endocrine Society · 2019Article
- Observational
- Clinical Outcomes After Unilateral Adrenalectomy for Primary Aldosteronism.JAMA surgery · 2019Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unilateral primary aldosteronism (PA) is often treated with adrenalectomy, but hypertension resolution rates are variable. A valid estimate of the postoperative normotension rate is necessary to inform the utility of PA testing and treatment. The authors searched MEDLINE In-Process & Other Non-Indexed Citations, Embase, and Cochrane Central Register of Controlled Trials. Prospective adult cohort studies with surgically treated PA that reported resolution of hypertension without the aid of medications were included. Among 2620 abstracts identified by the search, 25 studies in the systematic review with data on 1685 patients were investigated. The pooled proportion of normotension following adrenalectomy was 52% (95% confidence interval, 0.44-0.60). Meta-regression demonstrated a significant negative association between length of follow-up and proportion of normotension, with normotension dropping by 6.7% per year of follow-up (coefficient -0.006; 95% confidence interval, -0.01 to 0.002). Overall, approximately half of the patients experienced hypertension resolution, although this outcome may not be durable in all patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.