Evidence map›Paper›PMID 27759161›Full record

ArticleEuropean journal of immunology2017

Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.

Guoping Fu, Mei Yu, Yuhong Chen, Yongwei Zheng, Wen Zhu, Debra K Newman, Demin Wang, Renren Wen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Guoping FuThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Mei YuThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Yuhong ChenThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Yongwei ZhengThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Wen ZhuThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Debra K NewmanThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Demin WangThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Renren WenThe Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA.
Versiti Blood Center of Wisconsin · USMedical College of Wisconsin · US

Funding

PLC?s in B cell biology and autoimmunityR01AI079087 · NIAID · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2008 to 2018
$4.4M
Stat5 dephosphorylation by Shp-2R01HL073284 · NHLBI · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2003 to 2007
$1.3M
Individual and Collaborative Roles in T Cell ActivationR01AI052327 · NIAID · BLOODCENTER OF WISCONSIN, INC. · PI WEN, RENREN · 2002 to 2005
$1.1M
NHLBI NIH HHS R01 HL073284NIAID NIH HHS R01 AI052327NIAID NIH HHS R01 AI079087
6 · The paper itself

Abstract

Pre-T cell receptor (TCR) signaling is required for pre-T cell survival, proliferation, and differentiation from the CD4 and CD8 double negative (DN) to the double positive (DP) stage. However, the pre-TCR signal transduction pathway is not fully understood and the signaling molecules involved have not been completely identified. Phospholipase Cγ (PLCγ) 1 is an important signaling molecule that generates two second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, that are important to mediate PKC activation and intracellular Ca

Indexed as

Cell DifferentiationSignal TransductionAnimalsBiomarkersCalciumCell ProliferationCell SurvivalExtracellular Signal-Regulated MAP KinasesGene ExpressionGenotypeLymphocyte ActivationMiceMice, TransgenicPhospholipase C gammaPhosphorylationPrecursor Cells, T-LymphoidBiomarkersCalciumExtracellular Signal-Regulated MAP KinasesPhospholipase C gammaReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaPhospholipase Cγ1Pre-T cellPre-TCRSignal transductionT-cell development

Identifiers

PMID27759161
PMCPMC5559087
OpenAlexW2537799114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.