ArticleScientific reports2016
Spatial Dependence of DNA Damage in Bacteria due to Low-Temperature Plasma Application as Assessed at the Single Cell Level.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Cold atmospheric plasma mediates antibiofilm activity and sensitization to further plasma and antibiotic challenges againstFEMS microbes · 2026Article
- Sublethal Damage Caused by Cold Plasma onFoods (Basel, Switzerland) · 2024Article
- The cold atmospheric pressure plasma-generated species superoxide, singlet oxygen and atomic oxygen activate the molecular chaperone Hsp33.Journal of the Royal Society, Interface · 2023Article
- Antibacterial efficacy of non-thermal atmospheric plasma against Streptococcus mutans biofilm grown on the surfaces of restorative resin composites.Scientific reports · 2021Article
- Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism.Biomedicines · 2021Review
- Genotypic and Phenotypic Changes inInternational journal of molecular sciences · 2020Article
- Reproducibility of 'COST reference microplasma jets'.Plasma sources science & technology · 2020Article
- Evolution of the Surface Wettability of PET Polymer upon Treatment with an Atmospheric-Pressure Plasma Jet.Polymers · 2020Article
- The molecular chaperone Hsp33 is activated by atmospheric-pressure plasma protecting proteins from aggregation.Journal of the Royal Society, Interface · 2019Article
- Nontarget Biomolecules Alter Macromolecular Changes Induced by Bactericidal Low-Temperature Plasma.IEEE transactions on radiation and plasma medical sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Low temperature plasmas (LTPs) generate a cocktail of reactive nitrogen and oxygen species (RNOS) with bactericidal activity. The RNOS however are spatially unevenly distributed in the plasma. Here we test the hypothesis that this distribution will affect the mechanisms underpinning plasma bactericidal activity focussing on the level of DNA damage in situ. For the first time, a quantitative, single cell approach was applied to assess the level of DNA damage in bacteria as a function of the radial distance from the centre of the plasma jet. Salmonella enterica on a solid, dry surface was treated with two types of LTP: an atmospheric-pressure dielectric barrier discharge plasma jet (charged and neutral species) and a radio-frequency atmospheric-pressure plasma jet (neutral species). In both cases, there was an inverse correlation between the degree of DNA damage and the radial distance from the centre of the plasma, with the highest DNA damage occurring directly under the plasma. This trend was also observed with Staphylococcus aureus. LTP-generated UV radiation was eliminated as a contributing factor. Thus valuable mechanistic information can be obtained from assays on biological material, which can inform the development of LTP as a complementary or alternative therapy for (topical) bacterial infections.
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Registered trials
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