Observational studyEuropean journal of clinical nutrition2017
Lower thigh muscle mass is associated with all-cause and cardiovascular mortality in elderly hemodialysis patients.
Observational study in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Utility of ultrasound in measuring quadriceps muscle thickness in patients receiving maintenance hemodialysis: comprehensive systematic review and meta-analysis.Clinical and experimental nephrology · 2025Pooled it
- Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients.BMC nephrology · 2023Trial
- Longitudinal change in thigh muscle cross-sectional area in association with hospitalization among patients undergoing hemodialysis: the Osaka Dialysis Complication Study (ODCS).Clinical and experimental nephrology · 2026Observational
- Association between appendicular skeletal muscle mass and myocardial glucose uptake measured byESC heart failure · 2025Article
- The usefulness of a body shape index in assessing muscle function and strength in older adults hemodialysis patients.Frontiers in endocrinology · 2025Article
- Myosteatosis: an underrecognized risk factor for mortality in non-dialysis chronic kidney disease patients.Journal of nephrology · 2024Article
- Thigh muscle by CT images as a predictor of mortality in patients with newly diagnosed colorectal cancer.Scientific reports · 2024Article
- Thigh muscle mass evaluated by point-of-care ultrasound is associated with short-term mortality in patients with sepsis in the emergency department.Scientific reports · 2024Observational
- Making the invisible visible: imaging techniques for assessing muscle mass and muscle quality in chronic kidney disease.Clinical kidney journal · 2024Review
- Concordance between muscle mass assessed by bioelectrical impedance analysis and by muscle ultrasound: a cross-sectional study in a cohort of patients on chronic hemodialysis.BMC nephrology · 2024Article
- Article
- Physical performance and muscle strength rather than muscle mass are predictor of all-cause mortality in hemodialysis patients.Frontiers in public health · 2023Article
- Low skeletal muscle mass by computerized tomography is associated with increased mortality risk in end-stage kidney disease patients on hemodialysis.Journal of nephrology · 2022Article
- Risk Factors Affecting Muscle Mass Decline in Maintenance Hemodialysis Patients.BioMed research international · 2022Article
- Usefulness of computed tomography-measured psoas muscle thickness per height for predicting mortality in patients undergoing hemodialysis.Scientific reports · 2021Article
- Systematic review and meta-analysis of lean mass and mortality: Rationale and study description.Osteoporosis and sarcopenia · 2021Article
- Muscle mass assessment in renal disease: the role of imaging techniques.Quantitative imaging in medicine and surgery · 2020Review
- Intradialytic Nutrition and Hemodialysis Prescriptions: A Personalized Stepwise Approach.Nutrients · 2020Review
- Observational
- Muscle mass assessment by computed tomography in chronic kidney disease patients: agreement with surrogate methods.European journal of clinical nutrition · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesHigher body mass index appears protective in hemodialysis patients, although it remains to be determined which component of muscle or fat mass is primarily associated with this survival advantage. SUBJECTS/
methodsEighty-one hemodialysis patients in our institution were prospectively followed from July 2011 to August 2015. Muscle and fat mass were evaluated by measuring the cross-sectional areas of the thigh and abdomen using computed tomography. The relationship between muscle and fat mass, and all-cause and cardiovascular mortality was studied using the Kaplan-Meier analyses and multivariate Cox proportional hazard models.
resultsDuring more than 4 years of follow-up, 26 patients (32%) died. In the Kaplan-Meier curve analyses, lower thigh muscle mass was significantly associated with all-cause and cardiovascular mortality (log-rank test, P<0.01 and P<0.001, respectively), but there was no such association with thigh fat, abdominal muscle and fat mass levels. In multivariate Cox proportional hazard models, each 0.1 cm
conclusionsLower thigh muscle mass is significantly associated with all-cause and cardiovascular mortality in hemodialysis patients. Our findings indicate the importance of focusing on the muscle mass of lower extremities to predict the clinical outcomes of hemodialysis patients.
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Registered trials
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