Evidence map›Paper›PMID 27759045›Full record

ArticleScientific reports2016

Transient Induced Molecular Electronic Spectroscopy (TIMES) for study of protein-ligand interactions.

Tiantian Zhang, Ti-Hsuan Ku, Yuanyuan Han, Ramkumar Subramanian, Iftikhar Ahmad Niaz, Hua Luo, Derrick Chang, Jian-Jang Huang, Yu-Hwa Lo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiantian ZhangMaterials Science and Engineering Program, University of California San Diego, La Jolla, California 92093-0418, USA.
Ti-Hsuan KuDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA.
Yuanyuan HanDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA.
Ramkumar SubramanianDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA.
Iftikhar Ahmad NiazDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA.
Hua LuoDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0407, USA.
Derrick ChangDepartment of Nanoengineering, University of California San Diego, La Jolla, California, 92093-0448, USA.
Jian-Jang HuangGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, 10617, Taiwan.
Yu-Hwa LoMaterials Science and Engineering Program, University of California San Diego, La Jolla, California 92093-0418, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a method, Transient Induced Molecular Electronic Spectroscopy (TIMES), to detect protein-ligand interactions without any protein engineering or chemical modification. We developed a physics model for the TIMES signal and mathematically formulated the problem to attain physical insight of protein-ligand interactions without any disturbances by molecular probes, fluorescent labels, or immobilization of molecules. To demonstrate the functionality of this method, we have used the TIMES signals to find the dissociation constants for the affinity of reactions, the shear-stress dependent adsorption time of molecules on surface, and other interesting features of protein-ligand interaction in native conditions. As a unique tool, TIMES offers a simple and effective method to investigate fundamental protein chemistry and drug discoveries.

Indexed as

MicrofluidicsModels, TheoreticalAnimalsDrug DiscoveryHumansLigandsProtein BindingProteinsSpectrum AnalysisLigandsProteins

Identifiers

PMID27759045
PMCPMC5069662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.